Thank you so much for this presentation; excellent description of the glutamate hypothesis in schizophrenia, invaluable in helping with my revision and interview prep.

Research shows: "Augmentation of sarcosine, a natural inhibitor of the glycine transporter type I, normalizes glutamatergic neurotransmission, having a beneficial impact on primary negative symptoms in schizophrenia and may also influence immune system and interleukin 6 (IL-6) levels. Finding a relationship between initial IL-6 serum concentrations or its changes and severity of symptoms as a result of sarcosine addition to stable antipsychotic treatment. Fifty-eight individuals with schizophrenia with predominantly negative symptoms completed a 6-month randomized, double-blind placebo-controlled prospective study. Patients received 2 g of sarcosine (n = 29) or placebo (n = 30) daily per os. We measured IL-6 levels and severity of symptoms at the beginning, after 6 weeks and 6 months. As the main clinical tools, we used the Positive and Negative Syndrome Scale (PANSS) and Calgary depression scale for schizophrenia (CDSS). Augmentation with sarcosine had no effect on IL-6 serum levels in all time points. We noted significant improvements in negative symptoms, general psychopathology, and total PANSS score in the sarcosine group. We found a correlation of initial serum IL-6 with the severity of positive symptoms and a negative association between IL-6 levels reduction and positive symptoms reduction. Sarcosine does not significantly affect IL-6 concentrations but IL-6 may be involved in mechanisms related to the presence of positive symptoms. Copyright © 2018 John Wiley & Sons, Ltd. " www.science.gov/topicpages/g/glutamatergic+compounds+sarcosine

@criticadorauniversal

3 жыл бұрын

Can you summarize it for me so that I understand? is it supposed to have served the negative symptoms yes or no?

@criticadorauniversal

3 жыл бұрын

Can you summarize it for me so that I understand? is it supposed to have served the negative symptoms yes or no?

This is brilliant , thank you!

using this to put me to sleep

This would explain also why autistic folks are more prone to developing psychosis, due to the excess glutamate.

I have theorized that both glutamate and dopamine play a role in schizophrenia but dopamine is comparable to a mere toppled domino because it is important to creating the overall symptoms that define schizophrenia but it’s not the cause, also Glutamate and dopamine are linked and levels of each influence the other this explains why anti psychotic drugs are effective at mainly treating the “Positive Symptoms” and Glutamate Antagonists are only effective at treating the “negative symptoms,” but what if we used both??🤯🤯 Also where’s the FDA they need to get a look at this

@jeanpaultongeren125

Жыл бұрын

How do you know if you have shizophrenia?. I had psychosis 6 times. The negative symptons I have are because of the medictaion.

@agentbertmacklin9880

Жыл бұрын

@@jeanpaultongeren125 yes antipsychotic medications shrink grey matter and cause side effects, do to the reoccurring of symptoms I would look into getting a diagnosis… however if you do want to help negative symptoms I recommend talking to your doctor about lowering the antipsychotics dosage and then pairing it with 200mg panax ginseng and 500mg NAC and 250mcg of selenium to regulate glutamate and reduce negative symptoms. If you become manic from panax ginseng you have bipolar, if it helps you likely have schizophrenia. If it does both you may have schizoaffective disorder. Which is both diseases. Once again talk to your doctor first before trying anything but the studies for panax ginseng are promising. It’s treats both negative and positive symptoms.

@jeanpaultongeren125

Жыл бұрын

@@agentbertmacklin9880 Thanks

Excellent!

Educative

So I could get schizophrenia from using dissociatives regularly?

This was excellent! Thankyou. Could u pls provide me with the references?

I'm trying to recover from solvent induced psychosis, it's very similar to pcp induced psychosis, no anti psychotics including clozapine have ever worked, it's very difficult to understand this stuff while suffering from psychosis but I'm doing my best, Iv only recently learned there's been long term alterations to nmda activity caused by Touline, I was doing high doses of Glycine and am currently using the glycine re-up take inhibitor Sarcosine, that covers Glycine but what do I do to regulate glutamate activity?, Iv read there's an nmda antagonist medication memante ( not spelled correctly ), it's prescribed for Alzheimer's but I'm hoping I can get an off label script, Iv seen a study that used it to treat psychosis in schizophrenia, will that medication normalize nmda activity? Iv also seen a study on boosting bdnf to normalize nmda activity so Iv taken 12 gram's of Dihexa and about to start the synthetic version of cerebrolysin called p21. Can anyone comment on my situation?

@PhunkyPharmacologist

3 жыл бұрын

I would not recommend memantine or any other antagonists as it is believed that NMDA signaling is already low. There are currently no potentiators available for clinical use. D-cycloserine showed modest benefits in some patients, but discuss this with your psychiatrist first.

@kaydee3407

2 жыл бұрын

There are anti phospholipase a2 natural inhibitors.. That reduces glutamate activity .. The former is associated with brain inflammation .. Use the relevent research keywords Also read up on phosholipase amd astrocytes . A good research is below with contact email of researcher . Its about covid but expkains chemistry of pla2 and gives natural options and alopathic options Utube : achiless heel phospholipase a2 And dont take the vaccine ..it increases pla2

@RodrigoOswego

Жыл бұрын

Have you heard of 4dma-78dhf ?

thank you. how much glycine?

What if it is dopamine auto antibodies? So the new title of the disease would be anti dopamine (1-5) receptor encephalitis?

@Wabbelpaddel

9 ай бұрын

That would likely be a form of parkinsons. Anti-NMDAR autoantibodies can sometimes cause a severe form of schizophrenia.