Biochemistry | Enzyme Inhibition

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Ninja Nerds!
In this lecture Professor Zach Murphy will present on enzyme inhibition. We hope you enjoy this lecture and be sure to support us below!
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#ninjanerd #EnzymeInhibition #Biochemistry

Пікірлер: 230

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    @Dopamine-.-

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    @shahdma7moud59 ай бұрын

    This guy explains wayy better than my lecturer at the uni !

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    @aramideolaleye Жыл бұрын

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    @nominationpub7784 жыл бұрын

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  • @Osteoclast

    @Osteoclast

    Жыл бұрын

    same ong, damn thats a 2year old comment

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    @ishmaeltetteh9964 Жыл бұрын

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  • @levijohnson1214
    @levijohnson12146 жыл бұрын

    Wow! You've been such a revelation to me. Thank you very much. These videos are obviously very easy to understand, and they give me so much confidence in Bich now.

  • @munisashakhova1603
    @munisashakhova16032 жыл бұрын

    No book can explain like you!!!! Thank you soo much! I love your lessons :)

  • @rubisco_biscotti
    @rubisco_biscotti2 жыл бұрын

    I just memorized the effects of inhibition for 4 years during pre-med without understanding no matter how much I tried reading about it. Now I am so happy to find your channel to understand the materials intuitively in med school LOL. DEFINITELY is gonna help me retain all of this long term now. I was hesitant at first seeing the first MM equation video's derivations but it makes perfect sense why you went through the trouble to explaining the whole thing. THANK YOU!

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    @berniceamanor8162

    2 жыл бұрын

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    @waddywaddy72482 жыл бұрын

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  • @naty1014
    @naty10143 жыл бұрын

    Thanks to you I passed biochemistry, really great work, keep doing it because you help a lot, thanks to you from the heart...!!!

  • @victoriacollinson1027
    @victoriacollinson10273 жыл бұрын

    You’re an awesome teacher, your completely explain things that I’ve tried to get for months! Tank you so much... keep making videos :D

  • @helenJuice
    @helenJuice6 жыл бұрын

    Its been really great watching your videos and you are making medical school so much easier for a lot of us out here. thank you so very much and God bless

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    @christopherbombela22845 жыл бұрын

    I learn more from your vids that I do in class

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    @ThatOneScienceGuy3 жыл бұрын

    This guy is great. Wish he had videos about everything I'm learning this semester because my professor sucks.

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    @IraRiritEATSurBRAIN6 жыл бұрын

    god bless this has been soooo helpful!! Thankyouuu

  • @sciencenerd7639
    @sciencenerd76393 жыл бұрын

    Thank you for doing a thorough explanation. I appreciate that you included examples.

  • @user-ni6id3zy3r
    @user-ni6id3zy3r5 жыл бұрын

    Thanks for your efforts and all whom helping you to make these lecture clear and easy 🙏❤️😊❤️😊😊❤️

  • @Reree-gz5bg
    @Reree-gz5bg3 жыл бұрын

    much appreciation for taking the time to draw this all out :)

  • @mugambiismbaya
    @mugambiismbaya4 жыл бұрын

    I am currently for my pharmacy and poisons board exams and this video was really helpful. thank you. God bless you.

  • @oxell4925
    @oxell49253 жыл бұрын

    Great explanations, very clear, very helpful. THANK YOU!

  • @miriambendayan6530
    @miriambendayan65308 ай бұрын

    Your literally the best teacher ever! Never have I understood topics like this before your videos

  • @GeorgeAlexx
    @GeorgeAlexx2 жыл бұрын

    His lectures are so clear and easy to understand

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    @medjournals52353 жыл бұрын

    I love your videos they are so creative as I'm a visual learner, It helps a lot in Med School.

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    @zahraab5014 Жыл бұрын

    man if i pass my biochem final im gonna pray for you so much ill start appearing in your dreams

  • @bryanh8292
    @bryanh82924 жыл бұрын

    Slight correction: for a competitive inhibitor higher km = decreased affinity for substrate

  • @jakephelps4766

    @jakephelps4766

    2 жыл бұрын

    you are essentially saying the same thing....in the last video he talked about how at 1/2vmax [s]=km so the km is basically telling you the concentration of substrate required to reach vmax....he talked about how basically increasing km results in decreased substrate affinity i.e you need to increase [s] to reach vmax

  • @CutiePieDIY

    @CutiePieDIY

    Жыл бұрын

    thank you i was just wondering this!!

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    @dannmwangi8513 жыл бұрын

    Keep your mind clear 😂😂😂 cox😂😂 this guy has a sensational sense of humor

  • @galaxy5149
    @galaxy51498 ай бұрын

    I'm a french student who's not good at english but i understand everythink thank you for this video

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    @dollmonn36413 жыл бұрын

    These videos are addictive! 😊😊

  • @10knovideoschallenge32
    @10knovideoschallenge325 жыл бұрын

    This is really helpful ! Thanks ❤

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    @ahmedsamibakhti47545 жыл бұрын

    You are the best " a learned man and cool guy "

  • @mansoursediqi7606
    @mansoursediqi76064 жыл бұрын

    You are helping humanity by teaching thanks so much

  • @jeffersonfilberttjoenardi6644
    @jeffersonfilberttjoenardi66445 жыл бұрын

    I think something is off about the Competitive Inhibitor. If the Substrate Affinity goes up, the KM decreases, but as the Substrate Affinity goes down the KM increases. You explained that to beat the Competitive Inhibitor the Substrate Affinity must go up thus the KM will increase. No, I think the correct explanation is because the Competitive Inhibitor beat the Substrate's Affinity, the Substrate Affinity goes down hence the KM goes up. Because the effect of Competitive Inhibitor is KM goes up but Vmax unaffected. That's all from me, anyway amazing video! Really helps me understand difficult concepts!

  • @TheForeverFalcon

    @TheForeverFalcon

    4 жыл бұрын

    Why does the Km decrease of 'uncompetitive inhibition' then? How has the substrate infinity increased?

  • @chelsysagastume8296

    @chelsysagastume8296

    4 жыл бұрын

    yes, it's true the rise in Km means that there is a lower substrate affinity for the substrate and enzyme to make ES complex due to low km it takes for inhibitor as well as the high affinity for the inhibitor. So because enzyme has high affinity for the inhibitor it must be fixed. To fix it he has to increase the substrate concentration.

  • @gleefulreaper

    @gleefulreaper

    2 жыл бұрын

    Thnx ❣

  • @mariapalacios533

    @mariapalacios533

    2 жыл бұрын

    I agree! but awesome video still...

  • @nas_775
    @nas_7755 ай бұрын

    Thank you soo much professor, you have a gift of making anything understandable!!!

  • @nesie7336
    @nesie73362 жыл бұрын

    WOW!! You are the best!! Thank you so much for being a super duper awesome teacher!!!

  • @samar9211
    @samar92112 жыл бұрын

    I can’t imagine that I could have learnt it better Thanks doctor 💙💙💙💙🌎

  • @Izzati-n3t
    @Izzati-n3t14 күн бұрын

    Thank You so much. Only your video makes me understand of the concept. :)

  • @katchyizuorah2761
    @katchyizuorah27612 жыл бұрын

    Really helpful, d best I've seen...tnk u Ninja

  • @davidmixer5320
    @davidmixer5320 Жыл бұрын

    Love it. Thanks, Z.

  • @fionaachola3375
    @fionaachola33754 жыл бұрын

    Am I student and wow...ur videos are really helpful....Was asking u guys to make a video on protein purification methods as well

  • @dmyymd7612
    @dmyymd76125 жыл бұрын

    At the end of the non competitive inhabitation, how is the inhabitant released and the pocket fixed or removed?

  • @drawwithnannu4562
    @drawwithnannu45625 жыл бұрын

    Very helpful video .thank you sir.

  • @fadelmilad3732
    @fadelmilad37325 жыл бұрын

    Love this guy!

  • @shaafaelahee3104
    @shaafaelahee31042 жыл бұрын

    Explanation really very clear.Thnks a lot

  • @No_1419
    @No_14194 жыл бұрын

    thank you for this video,really nice

  • @teamammcri2224
    @teamammcri22245 жыл бұрын

    Thanq for preking up the learning process😊.I have a doubt :disulfiram used to treat chronic alcoholism is an example of what type of inhibitor?

  • @lidapol873
    @lidapol8733 жыл бұрын

    Thank you so much. I did great on test just by watching your videos

  • @sipramayeeszoo-3087
    @sipramayeeszoo-30873 жыл бұрын

    You are the best tutor ever

  • @kellietowner3268
    @kellietowner32682 жыл бұрын

    Thank you so much for this video!!

  • @chandrukandhasamy2768
    @chandrukandhasamy27683 жыл бұрын

    Sir your lecture are brilliant and easy to understand.... and one thing I have request you to upload a snap of lecture you've done on board.... it is easy for revision also.....🙏

  • @ririjustine1745
    @ririjustine17454 жыл бұрын

    Woooow I just love ur lectures

  • @euginemasindesimiyu3856
    @euginemasindesimiyu38566 жыл бұрын

    Thank you much...how awesome

  • @nevecampbell513
    @nevecampbell5133 жыл бұрын

    This is amazing 🤩 Thank so much ninja nerd for making all these biochemistry lecture videos I really appreciate it 😊 could you replace my lectures on my biochemistry module?🥺

  • @Saakkyybb
    @Saakkyybb3 жыл бұрын

    Thank you Zach 😻

  • @heimenfaraj7942
    @heimenfaraj79422 жыл бұрын

    Thanks this really helped with my studies, I study medicine in barbados

  • @pclaudiag
    @pclaudiag3 жыл бұрын

    thanks professor Ninja! 🙌🏼

  • @clementmalky1394
    @clementmalky13943 жыл бұрын

    nice job this has helped me alot

  • @nadiashanaa7018
    @nadiashanaa70186 жыл бұрын

    careful! at 8:56! from what i understand, km has an INVERSE relationship with affinity. what's written on the board looks fine but when you say "km, or affinity, increases" is not!

  • @RajKumar-xy3mr

    @RajKumar-xy3mr

    6 жыл бұрын

    Km increases , it increases the substrate(S) concentration and decreases the substrate affinity

  • @user-qt8gd9id8n
    @user-qt8gd9id8n Жыл бұрын

    Very thankful … saved my marks in university

  • @nathanielsenderoff7951
    @nathanielsenderoff79514 жыл бұрын

    Thank you!

  • @taufiqhasanjisan1382
    @taufiqhasanjisan13825 жыл бұрын

    Sir plz make a video on metabolic acidosis and alkalosis...and buffer system

  • @itishere5278
    @itishere52782 ай бұрын

    So good!!!

  • @valdemarjohansen9496
    @valdemarjohansen94964 жыл бұрын

    Could you please make a nucleotide synthesis video? I really miss a nice and well-explained biosynthesis and degradation of purines and pyrimidines on youtube... Why won't you be the first? :))) Pleeeaasseeee

  • @Pete-da-peter
    @Pete-da-peter Жыл бұрын

    Lehninger takes 3 pages to explain this. you make life easier bro. love you

  • @otabekkushakov1109
    @otabekkushakov11095 жыл бұрын

    Bravo! Very well done - excellent superlative work, mate!

  • @samuelwilberforce8689
    @samuelwilberforce86896 ай бұрын

    fantastic teaching

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    @rmercer4 жыл бұрын

    These are the best writing markers I’ve seen, far better than Expo. Where can I get these??

  • @gomeznyirenda9943
    @gomeznyirenda99432 жыл бұрын

    Brah, best lecture class ever😅

  • @VJK.MD.
    @VJK.MD.6 жыл бұрын

    Thank you so much

  • @nnennayaowuala1908
    @nnennayaowuala19086 ай бұрын

    Ninja nerddddddddd❤❤❤❤❤. I don't even know how to say thank you. Thank God for u o 🙏

  • @stepup5338
    @stepup53382 ай бұрын

    Thankyou so much!

  • @izabelabozanic6825
    @izabelabozanic68255 жыл бұрын

    thank you!!

  • @AdityaKumar-eq6sy
    @AdityaKumar-eq6sy3 жыл бұрын

    Are the videos in the playlists in order ??? because at times they dont seem to follow a content flow

  • @languageandmana9255
    @languageandmana92552 жыл бұрын

    Wow!!!!!! You are the best teacher i've ever seen😳😳😳😍👏👏👏👏 You are a huge help for online international students like me who do not have any teacher just pdfs and some imperfect videos! But YOU are the best, you are better than all videos and all PDFs! Please keep doing new videos as all Health science students deeply need you! Thank you for your being. I just started to watch all of your videos and i hope to watch more videos uploading on youtube from you🙏💯💯💯💯💯

  • @Drestutoring
    @Drestutoring3 жыл бұрын

    One day I hope to be this good! Trying to be a prof 😭

  • @mariociencia12
    @mariociencia122 жыл бұрын

    Fantastic!

  • @annse_se
    @annse_se4 жыл бұрын

    Dude, I just got an A in Biochem with the help of your explanations! I am eternally grateful! Greetings from Croatia ✌

  • @rheillycarrasco470
    @rheillycarrasco4704 ай бұрын

    you’re the reason i’ll be able to go to med school one day

  • @urjotsingh5354
    @urjotsingh53543 жыл бұрын

    very helpful

  • @Rand22.2
    @Rand22.28 ай бұрын

    You are amazing❤

  • @heaven0107
    @heaven0107 Жыл бұрын

    amazing explanation 🤟

  • @dawnbrown9962
    @dawnbrown99625 ай бұрын

    Thanks!

  • @nadineem3376
    @nadineem33763 жыл бұрын

    good explanation but I've got one question or one thing I don't understand. You said that when the substrate concentration will increase the Km will increase to and so the affinity. In the first part of the video you said that a high Km means that the enzyme has low substrate affinity. So how can the affinity become high in competitive inhibitor when the Km and substrate concentration increases?

  • @gleefulreaper

    @gleefulreaper

    2 жыл бұрын

    This , i am confused as well

  • @anthonypeltier4039

    @anthonypeltier4039

    2 жыл бұрын

    Their website is up and running with all these videos and extensive notes on them, so I guess more extensive than the videos are already, I’m going to check it out to seek clarification

  • @Dr.Ghalebsaleh

    @Dr.Ghalebsaleh

    15 күн бұрын

    I think the idea, some enzymes have low affinity towards substrate so it has to reach high km in order to compete with the inhibitor and make the reaction

  • @dv_wild
    @dv_wild3 жыл бұрын

    man you are awesome ❤️

  • @ritwikrahul460
    @ritwikrahul4606 жыл бұрын

    Thanks sir

  • @raunakazim927
    @raunakazim9272 жыл бұрын

    i'm very confused, last video you said increase in Km results in decrease of substrate affinity . so how do they both increase in this case? arent they inversly proportional?

  • @deekshasingh798
    @deekshasingh7982 жыл бұрын

    thank you soo much

  • @mathiasselin1522
    @mathiasselin15224 жыл бұрын

    How can a certain amount of substrate in a cell be specific when there is different amounts of enzymes in a cell at any given moment?

  • @andrewcatimbang1509
    @andrewcatimbang15093 жыл бұрын

    Hi Ninja nerds. Do you know the exact order on how to view this playlist? Im ready to unlearn and relearn biochemistry.

  • @mavisdracula970
    @mavisdracula9702 жыл бұрын

    Thank you Thank you Thank you!!!

  • @mohammaddaryanavard7342
    @mohammaddaryanavard7342 Жыл бұрын

    Thanks a lot 🔥

  • @bandavedasri5816
    @bandavedasri58163 жыл бұрын

    Thank you so much bro

  • @symmetry5829
    @symmetry58294 жыл бұрын

    It makes everything so easy . Really helpful ,keep going,😊

  • @bboir
    @bboir Жыл бұрын

    For the longest I thought the active site changes shape when the inhibitor bind to the allosteric site. Will it change shape? Or I got that totally wrong during my university lecture.

  • @danieljames8823
    @danieljames88232 ай бұрын

    You are the best✊✊✊

  • @sjmor6302
    @sjmor63022 жыл бұрын

    loved the Cox joke at the end

  • @pookie247
    @pookie247 Жыл бұрын

    amazing

  • @AsiehHamidian
    @AsiehHamidian8 ай бұрын

    You are best.tank you