There are two Lupus Forum webinars in this series on Lupus nephritis. In webinar 1 Professor Ed Vital, chair of the Lupus Forum, is joined by two members of the Lupus Forum steering committee, Professor Maria Dall’Era and Professor Brad Rovin. The overall aim of the webinar series is to improve understanding of the pathophysiology of lupus nephritis, the importance of early diagnosis and the challenges of management and treatment. In webinar 1 the focus is on the challenges of management with standard therapies.