Ashwagandha - Anti-inflammatory Mechanism
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Ashwagandha - Anti-inflammatory Mechanism
Ashwagandha is a herb used in Indian medicine (Ayurvedic medicine) for nearly 3000 years. It is found in India, Middle East, and Africa. It is reported to have anti-inflammatory, anti-microbial, anti-diabetic, anti-hypertensive, neuroprotective, apoptogenic, and reproductive and hormone modulating effects.
Let's review anti-inflammatory aspects of this herb. We will discuss NF-kB pathway modulation.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Thursday, Jul. 13 2023 14:55 PM
DrBeen: Medical Education Online - DrBeen
www.drbeen.com/
Pharmaceutics | Free Full-Text | Ashwagandha (Withania somnifera)-Current Research on the Health-Promoting Activities: A Narrative Review
www.mdpi.com/1999-4923/15/4/1057
Pharmaceutics | Free Full-Text | Ashwagandha (Withania somnifera)-Current Research on the Health-Promoting Activities: A Narrative Review
www.mdpi.com/1999-4923/15/4/1...
Ashwagandha - Special Subjects - Merck Manuals Consumer Version
www.merckmanuals.com/home/spe...
ASHWAGANDHA: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews
www.webmd.com/vitamins/ai/ing...
Ashwagandha root extract exerts anti‑inflammatory effects in HaCaT cells by inhibiting the MAPK/NF‑κB pathways and by regulating cytokines
www.spandidos-publications.co...
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study | Signal Transduction and Targeted Therapy
www.nature.com/articles/s4139...
Frontiers | NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration
www.frontiersin.org/articles/...
fimmu-10-00705-g002.jpg (1084×813)
www.frontiersin.org/files/Art...
fimmu-10-00705-g001.jpg (1084×813)
www.frontiersin.org/files/Art...
Frontiers | What Is Nuclear Factor Kappa B (NF-κB) Doing in and to the Mitochondrion?
www.frontiersin.org/articles/....
IκBα - Wikipedia
en.wikipedia.org/wiki/I%CE%BA...
Пікірлер: 94
funny this comes up as I sit drinking a mug of herbal tea with one huge spoonful organic ashwaganda powder added to help sleep....works for me. Love it!
I started taking ashwaghanda daily after learning about it from Dr. Berg 13 days ago. I did not feel a difference in pain relief until maybe last 2 days, but my Garmin watch detected my overnight stress levels were greatly improved the immediately (Measured by analyzing heart rate variability). To test that it was an ashwaghanda effect I skipped taking a daily dose (1/3 morning, 2/3 at bedtime) and my sleeping stress levels were elevated again that night. This short period of using ashwaghanda seems to show a positive effect as a stress adaptogen so far.
@jass412
11 ай бұрын
can I ask what dose did you take per day ? I like dr berg too
@jmc8076
11 ай бұрын
Dr Berg like many on social media giving medical/health advice is not an MD or scientist or researcher. He’s been corrected a few times by credible channels incl Physionic who is a molecular researcher.
@andreastarks2780
11 ай бұрын
@@jmc8076 actually he is a scientist and he is a researcher and you don’t have to be an MD to be that, he does know nutrition and he does know metabolic health and physiology. You don’t have to be an MD to know that. I am and MS and I trust myself over my GP. I’ve tester her discussion topics she’s never reviewed the latest scientific literature and she has failed.
@andreastarks2780
11 ай бұрын
@@jass412 I’m using his supplement if you want to look for that to see the dosage, just so that I don’t get accused by SOME in these comments that I’m not qualified to talk about benefits of ashwaganda that I have observed personally. /s
@jass412
11 ай бұрын
@@andreastarks2780 thank you
Dr Been, This was a brilliant lesson in understanding this process. I'm a clinical herbalist. Thank you for touching the subject of this wonderful plant.
Dr. Been, I always love you illustrative drawings as they help to so clearly see the process rather than just hear it with no previous knowledge of these things to fall back on. Please continue to give us more info on the Ashwagandha. Example is it habit forming, does it adversely effect any organs in the body. Thanks for being on youtube for us!!!!
@DrBeenMedicalLectures
11 ай бұрын
Will do
Thank you Dr Been from France, I understood better few mechanisms in physiology that this great root can induce in our bodies! I Used it for years to have a better sleep! Very good plant
I love the way Dr Mobeen explains the pathways of different beneficial vitamins and medication!❤ What a shame that pharmaceutical companies don’t offer a similar explanation? Probably because their claims do not always hold up, no surprise there!! 🤔🤔🤔
I have used it for almost 10 years for anxiety. Good quality, and clean it's good
Thank you so much, Dr Been. And wow that’s amazing that you have an Ayurvedic in your family!
It good to hear a medical professional speaking about options other than prescription drugs. I enjoy your lectures and learn lots.
I signed up for your medical lectures online. Thanks for making this available. I love your drawings. They make difficult ideas more understandable.
If aswagandha inhibits NF-kB and TLR4, it can be anticancer as well. I use it for a better sleep during extended fasting.
why are you quoting big pharma sites. of course they do not recommend something natural that may help.
@briechilli4496
11 ай бұрын
So true !
I have been using aswagandha for past 3 years, it act as immune modulators. This is only of the herbs in this earth have amazing immune modulator. I have used for my child for skin rash, like over reaction by immune on skin.
TY Dr Mobeen. I wish all Drs had such legible handwriting as yours .
Yes, I'm interested in natural products. Thanks for the video.
Thanks doc! I'm considering trying this herb for it's potential benefits!
I already have Ashwaganda in my cabinet, however I have not researched it yet. Thank You, Dr. Been for the video.
I was prescribed ashwaganda when I was in India. It was helpful.
In Ayurveda, ashwagandha called king of herbs. Best way to take is with warm milk with black pepper.
@l.a.mdclinic2449
10 ай бұрын
Will it not irritate your stomach?
Ur drawings are amazing & perfect in every way ur cursive writing is beautiful & legible
Good show
Hello Dr Been, Firstly thank you so much for all your excellent information over the last two years. Secondly could you do a video on Mukta Vati which does contain ashwaganda, amongst other things. However Mukta Vati's main claim is to reduce blood pressure (which I have found to be the case for me). Do you have any knowledge of side effects, good studies and long term use? I would be most grateful 🙏 if you covered this subject.
I heard it's not good for people who have or are prone to overactive thyroid. That's common in my family so I've never used it.
@rosiej9231
11 ай бұрын
So it should help for those that are hypothyroid?
I took ashwagandha for adrenal insufficiency from longterm prednisone for over a yr but stopped based on good studies showed it lowers morn blood cortisol and I’m hypoglycemic. Also like you Dr Mobeen I felt good independent longterm studies were lacking.
Thank you that was so wonderful... yes please I would like to know more about ashwagandha... love the cartoons.. nemo must be out looking for Dory :)... I took ashwagandha and Macca and it seemed to help with menopause symptoms. It was recommended to are ashwagandha in the morning before food... Now the question I have being older and having spinal injuries and inflammation, I was prescribed CBD oil, can I take the two together? I am worried about serotonin syndrome if I take both. I dont want to wake up one morning and find myself dead ;)... ❤
It will reduce inflammation however It may cause adhedonia In many clients.. check it out
@HappyLife-wv5ms
10 ай бұрын
Similar to what an SSRI does?
You wouldn't recommend it for autoimmune disorders then? Love your illustrations by the way 🥰😆
If you want fast relief from anxiety, depression, ect. Take 400-800mg. magnesium capsules a day!!! It works every time, and it does not damage the internal organs!!! (Always ask your Dr. first!!!)
Ashwaghanda was an ingredient in an herbal blood pressure supplement that I took for about 6 months taking it about every 12 hours. The result for me was at first high thyroid and when stopping then low with finally a high TSH and very high TPO. If you look the ingredient up on google, it can affect the thyroid and this may causes a lot of problems for some people. I am currently on Thyroid meds to save my thyroid that was under an autoimmune attack I suspect from Ashwaghanda. I am not a doctor but I feel one should research this herb before attempting it and check your thyroid levels throughout.
It definitely works for stress. I always took it before job interviews and it was a blessing for my nerves. Like anything though-- I would suggest not being reliant on any substance if you can avoid it.
20:37 Thank you. Thank you!
@DrBeenMedicalLectures
11 ай бұрын
Pleasure
I have some in my cupboard. Cant remember why i brought it but i have used it a few times.😊
QQQ: Hi DrBeen, could please also do a video on Andrographis?
Hi drbeen...nice to hear you again especially talking about ashwhaghanda as a natural antiinflammatory agent. Just want to ask about its liver side effects...how is it common to occur.
Drbeen what is your best recommendation for Chronic Fatigue Syndrome. The mild numbing fatigue in particular?
All supplement tablets/capsules will have lots of fillers, bulking agents and goodness knows what else won't they? Is it possible to grow it ourselves and consume it that way? Would you use the leaves, stems, roots or seeds? Or all four? Raw or processed?
BauerteK CorP was visited by Indian Ministry of Health and they were fascinated to know that Bauertek is using Ayurveda Med in its production of natural medicine. Ashwaganda is one of the herbs used for RELAX® with Valerian and Saffron
I find it helps my anxiety
Please do some videos on milk thistle, nac, tudca and other supplements that benefit health
Please would you consider a lecture on Boswellia serratus... Mainly for chronic pain? 🤔😊
ThePotsyLady I can't find your you tube channel. Is your support group on your you tube channel?
What about if the person is using prescription medications? Where can we find out which medications are contraindicated with use of Ashwaganda?
I wiuld like to know the mechanism for anxiety, ?PTSD and why suggested for autism also.
Nightshades and Hashimotos? Was told not to use it.
What does Dr. Bean think about low-dose colchicine as anti-inflammatory???
Have you heard about Life Wave X39 ? they say they activate your own stem cells , is this true and do we have this in the United States??
Dr. Been: It seems to me that covid-induced thrombi are more resistant to dissolving than everyday thrombi. We need something that can help to dissolve thrombi. (Covid caused a thrombus to form in my heart. I just had my 2nd TEE, and in spite of heparin, Lovenox, and warfarin, the thrombus persists.)
@bajone02
11 ай бұрын
Have you looked at K2 for clearing up your veins? Learn on YT.
@djondjon
11 ай бұрын
@@bajone02 Thank you for your reply. Yes, I have been taking 90 mcg daily for a few years now.
@blutamis7697
11 ай бұрын
Nattokinase is the best natural option for blood clot or heart health after covid or the government measure.
@hiris1903
11 ай бұрын
If a blood clot has already formed then the meds you are on are to prevent it growing (heparin, lovenox, warfarin); meanwhile your body has the natural ability to slowly break down the existing clot. This must happen slowly to prevent an embolism breaking free and wreaking havoc. Your anticoagulants may need to continue long-term
@djondjon
11 ай бұрын
@hiris1903 Thank you for your input. Yes, the meds are to keep it from growing and also to dissolve it, but it seems that covid thrombi are more resistant to dissolve. (I have been able to find a couple of scientific studies accordingly.) My thrombus is in the left atrium, and when originally found, was defined as medium-sized and partially mobile. A subsequent TEE a little over a week or so ago defined it as now large and partially mobile. I am supposed to have another TEE in about 3 mo. In the meantime, I just had CT AngioHeart W 3D Imaging / Function. I don't have results yet. And yes, I understand that I am going to have to be on Coumadin probably for the rest of my life.
Ashwagandha is the best adaptogen …
I have stage 3 lymphedema in one leg and it didn’t help me at all 🤷🏻♀️ though maybe it doesn’t help that type of issue
I am confused as to how the immune gets boosted but inflammation reduces :( inflammation is caused by the immune activity, no? For instance, for vaccine injured person who's taking immunosuppressive drugs... it's confusing.
@DrBeenMedicalLectures
11 ай бұрын
It reduces the NF-kB pathway. However, helps increase immune cells. So boosts some immune cells. Reduces the function of other. This is why some folks see no effect.
4:53 the number of “cover your ass” declarations on nursing mothers always angers me. In general, nursing with various herbs is far far FAR less likely to be an issue than during pregnancy. It’s not impossible there’s a small potential for crossing into the milk, but if we know it can potentially cause miscarriage in pregnancy it can’t cause miscarriage with nursing so that one’s off the charts! A good reference for milk and meds is the actual book “medications and mothers milk” by Dr Thomas Hale. It’s a very interesting book, well worth the money. 👌🏻👌🏻
Better refer to an Ayurvedic expert about these plants
Ashwagandha is herb from Punjab.
I'm thinking topics like cellular behavior is where we shouyld point AI. It is so commplex and intricately interwoven. We have barely scratched the surface. Point AI away from social media. Social media made humans stupid - let's not train AI that way. Give it good/hard and beneficial problems to solve.
Inhaling the fragrance of an herb seems a lot like homeopathy to me. Very disappointing to hear this from you Drbeen
@DrBeenMedicalLectures
11 ай бұрын
It "seems a lot like homeopathy", hence, you are disappointed? Maybe read a bit more before making such comments. Here is a study for you to read before further commentary: www.ncbi.nlm.nih.gov/pmc/articles/PMC2793341/