Amrita A. Iyer (Baylor): Reprogramming in the Inner Ear: A Promising Path to Restore Hearing
Ғылым және технология
www.iBiology.org
Hearing loss, caused by the death of hair cells in the inner ear, is the third most common public health issue in the United States. Currently, there are no therapeutic strategies to restore hearing. In her thesis research, Dr. Amrita A. Iyer investigated the possibility of regenerating functional hair cells by reprogramming non-hair cells of the mouse inner ear. She found that overexpression of a single transcription factor, ATOH1, can successfully reprogram non-sensory cells into hair cells with typical characteristics in neonatal mice. However, a combination of three transcription factors - ATOH1, GFI1, and POU4F3 - was required to reprogram inner hair cells in 1-week old mice. Her findings provide a window into the developmental and gene expression requirements for regeneration of inner ear hair cells in mammals, and may inform future therapeutic strategies for hearing loss in humans.
Speaker Biography: Dr. Amrita A. Iyer grew up in Bangalore in a home atmosphere that instilled in her a love for science and maths. After completing her schooling at Sri Kumaran Childrens Home (CBSE), she went on to pursue B.Tech in Biotechnology from VIT, Vellore. During the summer holidays of her bachelors, she did an industrial internship at Biocon, and a research internship at NIMHANS. Next, she did her Masters (by research) in Biological sciences from IIT Madras. After completing her masters, she came to the US in 2016 to pursue a doctoral degree in Molecular and Human Genetics at the Baylor College of Medicine.
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Пікірлер: 36
I am losing my low and high frequency hearing at a younger age than expected-hopefully, this kind of research bears fruits! Keep up the great work
Research like this touches me in a way that music and seeing kindness and empathy between people does. Thanks so much for sharing, Amrita! Truly fantastic work. The sense of hearing is just incredible and still something taken for granted as long as you don't have trouble with it. If we can fix hearing-loss (and hopefully noise induced tinnitus at that) it will improve the quality of life for so many people.
@jandehaan9219
6 ай бұрын
She writes that mammals don’t regenerate haircells. This is not, according to me, completely right. The danish scientist Kirkegaard and his colleague discovered that there are bats( mammals) can regenerate their haircells. It was published in PubMed.
*_Question:_* Does this ATOH1 need to be constantly present for the gene to be expressed or is it like a toggle switch, once used the gene is permanently on?
Very interesting! thank you
Fascinating!
Very interesting! Please help us 🙏🏼 thanks for the Video
Brilliant
Great, even high school students can understant.
This is very interesting. I have recently experienced sudden sensorineural hearing loss, and as I'm sure you are aware doctors globally are debating whether the increase in reported cases is a result of long Covid or not. As my career relies heavily on my ears, this has been a devestating blow.
What if we already have a cochlear implant, can we still get this treatment? Or do we need to remove the implant?
Great Work..... i was overwhlemed listening to your research, just hope you find success in your research journey and provide great listening boon to the society. my father of a cochlear implated 4 year girl from india. i hope you find out miracle regenreation of hair cells in cochlear implanted children too as they have a whole life to live and hear. thanks and keep the good work up.....
Thank you for your work! I experienced hearing loss due to inner ear infection, possibly COVID. It came on very suddenly. It is devastating, and a problem I deal with every day.
@lightyagami47299
Жыл бұрын
So what you did to recover it
@nanceymcclure7128
Жыл бұрын
@@lightyagami47299 I'm still dealing with it.
@lightyagami47299
Жыл бұрын
@@nanceymcclure7128 I am just 16 and i am listening 50 percent less I just can't hear someone sitting next to me 🥺🥺 what should I do
@nanceymcclure7128
Жыл бұрын
@@lightyagami47299 Have you seen an audiologist? Or an ENT doctor? Do you have congestion.. your eustachian tubes may be blocked. Do you have any problems with balance, or have any dizziness?
@nanceymcclure7128
Жыл бұрын
@@lightyagami47299 Always use ear protection like ear plugs if running a vacuum cleaner or a hair dryer or anything else that makes noise..
🙏
Why are you testing it on new born mice? They have functioning hair cells.
I have 80 db hearing loss in my both ears. Is it possible to treat? I need your kind advise Any one please tell and help me, i have very bad feeling 😢
I REMEMBER WHEN I WAS 10 YEARS OLD I ATE A PIECE OF PRESERVED MEAT WITH TOO MUCH SALT. THAT TIME I GOT A HUGE EAR LOSS!
Hello Madam My name is Himanshu Kamdar.I am from India. My son is having waardenburg syndrome and he is having seviar to profound hearing loss and doctors suggest cochler implants if there any other options Please help 🙏
Gene therapy. (7:10)
I m not listening i m just reading subtitle
I'm sure this will be enlightening, but I'll be using the subtitles because with my perfectly adequate hearing THE SOUND QUALITY OF THIS RECORDING IS SO POOR THAT IT'S ACTUALLY HURTING MY EARS. Do you not have the resources to provide professional sound equipment? Please look into it for future videos.
It's close to miracle for me, i had a kind of accident in my left ear. I'm from India , I'd like to volunteer if it works... I'll provide my email or number,,if atleast someone is interested
I am 32 year old. I am deaf . My name is manikandan from madurai, India. Please help me .. madam number give me