Alzheimer's Disease - Pathology, Tangles, Beta Amyloids

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[Errata: In the early part of the video, I wrote recurrent function instead of recurrent infections. Please keep this in mind while studying.]
*It is an insidious, progressive, degenerative disease of the neurons.
*Alzheimer's incidence is increasing in developed nations.
*Alzheimer's disease is one of the most costly diseases to manage. Continuous care is needed, recurrent infections and dehydration are common.
Dr. Mobeen presents the pathophysiology of Alzheimer's disease. Following topics are discussed:
Anterolateral amnesia. (Loss of forming new memories.)
Speech disorders.
Mood imbalance.
Disruption of the executive functions of the brain. (Difficulty with decision making.)
Initiates at the Hippocampus.
Genes involved:
1-14 - Senilin
11 - SDLR1
21 - APP
19 - ApoE4
Alzheimer's can be early onset or late onset. Genes 19 and 21 are involved in the early onset Alzheimer's.
*Tau protein's role.
*Beta amyloid's pathologies. (A-Beta lipoprotein.)
*Role of alpha, beta, and gamma-secretase.
*Formation of senile plaques due to the beta and gamma-secretase action instead of alpha and beta-secretase.
*Immune system activation due to the senile plaque formation.
*Destruction of the brain tissue due to the inflammatory reaction due to the senile plaques.
*Clogging of the neural synapses by the senile plaque proteins.
*Loss of cytoskeletal integrity due to the disruption of the Tau proteins.
*Disruption of the nutrients flow from the neuronal cell body to the axonal terminal.
*Formation of the Tau aggregates.
*ApoE-4 gene's role is discussed.
*Widening of the sulci and gyri as a result of the degeneration is presented.
*Role of increased load of the APP protein or the gene up regulation forming APP. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. ...
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.

Пікірлер: 120

  • @robrahlf6379
    @robrahlf63795 жыл бұрын

    The BEST VIDEO AVAILABLE!!! This gentlemen Covers everything related to Alzheimer s from genes to pathology. Awesome presentation!

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    5 жыл бұрын

    Thank you for your kind note. This is an important topic and I wanted to make sure that the lecture contains sufficient material to allow good understanding of the currently known aspects of this disease. Hope we will have breakthroughs in this area soon.

  • @gaylegonzalez71
    @gaylegonzalez715 жыл бұрын

    This is amazing! You definitely have a talent for teaching, thank you for making this available!!

  • @marialock007
    @marialock0073 жыл бұрын

    I am studying Dementia Disease at the moment and your explanations was a blessing. Thanks a million.

  • @darrenwedge309
    @darrenwedge3096 жыл бұрын

    I am not a student ,but my mother's sadly has Alzheimers ,I feel I have learnt something from this lecture, I now have a better understanding of what's actually happening. I thank you for sharing your knowledge.

  • @Pegasi52
    @Pegasi528 жыл бұрын

    Excellent lecture! I was just listening to it, not even watching it and I still managed to understand everything through audio alone. Thank you very much!

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    8 жыл бұрын

    Good to know. Thank you for your feedback.

  • @ceciliawaingei
    @ceciliawaingei7 жыл бұрын

    Thank you so much for this brilliant lecture, sir!

  • @DahPff
    @DahPff4 жыл бұрын

    Wow! Your explanation was so amazingly clear! Thank you so much!

  • @jiaweiyu9150
    @jiaweiyu91505 жыл бұрын

    Detailed and easy to follow explanations! Thank you

  • @joshuadanielmonachan9225
    @joshuadanielmonachan92256 жыл бұрын

    amazing lecture thank you and keep up the good work sir, you have my support

  • @boggiecity
    @boggiecity6 жыл бұрын

    Thanks you so much for this lecture, much love from Ecuador.

  • @deerk2225
    @deerk22255 жыл бұрын

    This is a very detailed explanation! Thank you so much ! Amazing 🙌🏻🙏🏻

  • @annatomczy5435
    @annatomczy54355 жыл бұрын

    What an amazing teacher! You are a hero and this is the best video on yt. I am amazed

  • @techdadfranco7542
    @techdadfranco75426 жыл бұрын

    You are simply great. You made it so easy. I am your apprentice from now

  • @siddiqakayani3329
    @siddiqakayani33295 жыл бұрын

    Thank you so much for explain all the mechanism in so much detail by making it easy

  • @carrotmeable
    @carrotmeable6 жыл бұрын

    Ur explanation helped made me understand a lot of holes in other lecturers explanations on the whole progression of alzheimers onset in an individual. Thank you so much!! Info will now be in my head for my final exam :)

  • @MMR_Alrajhi
    @MMR_Alrajhi6 жыл бұрын

    Thanks for this great lecture, it makes me clear with AD 👍🏻

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    6 жыл бұрын

    Good to know. Check out more lectures on drbeen.com. Study well my friend. Mobeen

  • @Ami-ej4yh
    @Ami-ej4yh3 жыл бұрын

    Excellent Lecture, much appreciated. Thank you.

  • @ingridosolo7791
    @ingridosolo77917 жыл бұрын

    EXCELLENT ,KEEP UP THE GOOD WORK

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    7 жыл бұрын

    Tx

  • @ibrahimkaya9787
    @ibrahimkaya97874 жыл бұрын

    This is very nice cover. Lipophagic dysfunction in AD would also be a chapter here.

  • @luckynicholus1687
    @luckynicholus16873 жыл бұрын

    Thank you so much sir for your deep explanation,you have really cleared all my doubts,look forward to watching more of your videos in the subsequent topics.

  • @ritalakhani1997
    @ritalakhani19976 жыл бұрын

    Amazing clarity.

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    6 жыл бұрын

    Thank you dear. Check drbeen.com for more lectures.

  • @Dineshkumar-cv9pd
    @Dineshkumar-cv9pd4 жыл бұрын

    best teacher ever.... thank you so much sir

  • @deepamvyas2984
    @deepamvyas29846 жыл бұрын

    Very reliable explanation; easy to understand ;best alzeimer lecture ever on youtube...you make every point clear sir;thanks for helping us sir....☺

  • @afaqperryhabib2438
    @afaqperryhabib24385 жыл бұрын

    Thank you Doctor, you saved my day

  • @kimberlyaguirre2758
    @kimberlyaguirre27587 жыл бұрын

    GREAT LECTURE!!!

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    7 жыл бұрын

    Thank you.

  • @aaris1697
    @aaris16977 жыл бұрын

    Thanks for your teaching, you really help me to understand Alzheimer's pathology

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    7 жыл бұрын

    Glad to be of help.

  • @somnathdasgupta5359
    @somnathdasgupta53596 жыл бұрын

    Thank you sir,it helped me a lot

  • @03amanshukla20
    @03amanshukla206 жыл бұрын

    Veryy goooood sir it really helps in my todays presentation.....very simple understanding.. .i wish that u were in our college...

  • @depthinnature
    @depthinnature6 жыл бұрын

    Sir It's really Amazing totally very conceptual...I love it..

  • @megha5595
    @megha55953 жыл бұрын

    sir plz make videos on cell injury and inflammation also....u r videos are super hit

  • @giovannapimentel9575
    @giovannapimentel95756 жыл бұрын

    Awesome! Thank you so much!

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    6 жыл бұрын

    +Giovanna welcome.

  • @maidee1671
    @maidee16713 жыл бұрын

    Tomorrow i will start my Masterthesis in AD-Research! thank you very much for this great and well pictured Information!!! Helped me a Lot! Greetings from Germany ✨ I wish you great functioning secretazes etc 😝

  • @elena123695
    @elena1236955 жыл бұрын

    awesome video !

  • @pallavipandey.
    @pallavipandey.6 жыл бұрын

    Thankyou sir It's very clear explanation

  • @amulyanera226
    @amulyanera2266 жыл бұрын

    Sir I follow ur immunology lectures ur anatomy and physiology lectures as well Am in mbbs first year Ur explanations helped me lot ND u know wt the cut copy paste of ur presentations in mine brought me many applause from my Dean as well.. Everyone in my college treat me as one of the most intelligent doctors but only I know it's only bcoz of u Thanq so much sir Thanq is a word which is not really enough to describe ur help but I can promise you that someday I will be a good doctor But still it's bcoz of u

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    6 жыл бұрын

    I am very happy for your passion for education my friend. I am also happy that we are adding value to your study sessions and then your professional career. Stay blessed and keep studying well. Stay in touch. I know you will be a great doctor. Mobeen

  • @doctorofpharmacologytoxico9556
    @doctorofpharmacologytoxico95563 жыл бұрын

    Thank you.

  • @pradhneshandhare7492
    @pradhneshandhare74925 жыл бұрын

    Very well explained Alzheimer condition sir, it was superb lecture.

  • @mashart4741
    @mashart47413 жыл бұрын

    Best explanation of Alzheimer's ever..thanku so much you save my time 👌

  • @jaisrikrishnakijai9144
    @jaisrikrishnakijai91446 жыл бұрын

    Excellent lecture it's was great to see your lecture

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    6 жыл бұрын

    Thank you, dear. Did you check drbeen.com/courses yet? We have tons of more lectures there.

  • @PrabhatKumar-mu1nr
    @PrabhatKumar-mu1nr6 жыл бұрын

    Thank You Sir,

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    6 жыл бұрын

    Welcome. Did you check the rest of the nervous system lectures on drbeen.com?

  • @sushmasingh8216
    @sushmasingh82164 жыл бұрын

    Thanku sir it's very helpful to understand this topic completely.

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    4 жыл бұрын

    You are most welcome!

  • @jyotidhaundiyal1339
    @jyotidhaundiyal13395 жыл бұрын

    Thnku sir to clear the concept about Alzheimer's pathophysiology .... Thanks a lot

  • @drmudfi
    @drmudfi7 жыл бұрын

    Nice lecture sir

  • @davidbarton774
    @davidbarton7746 жыл бұрын

    Hi, thanks for the video. I was wondering when the cell gets destroyed through the combined work of amyloid plaque and tau tangles, what remains. Does the neuron itself disappear leaving the tau tangles and amyloid plaque behind? Or does the neuron body remain, like dead debris in the brain?

  • @thechocola96
    @thechocola965 жыл бұрын

    Thank you

  • @emanab3661
    @emanab36615 жыл бұрын

    İts amazing Thank you very much Dr. From İraq

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    5 жыл бұрын

    You are very welcome. Love from the USA.

  • @fikaduwotasa1353
    @fikaduwotasa13534 жыл бұрын

    Thank you very much this week my presentation will on Alzheimer diseases and u help me a lot.

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    4 жыл бұрын

    Very good to know. Study well!

  • @fikaduwotasa1353

    @fikaduwotasa1353

    4 жыл бұрын

    Thank u

  • @amulyanera226
    @amulyanera2266 жыл бұрын

    Grt explanation

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    6 жыл бұрын

    Thank you.

  • @yumquickcook
    @yumquickcook3 жыл бұрын

    Sir can u suggest some papers on recent discoveries regarding Alzheimer's disease pathophysiology in brain.great video ,helps n research purposes

  • @drasma2516
    @drasma25167 жыл бұрын

    thank u sir!!!

  • @ninomumladze4619
    @ninomumladze46195 жыл бұрын

    Great lecture, Thanks Mr. Just one thing, isn't it supposed to be hyperphosphorylation of TAU protein rather than hyperpolarization?

  • @xDomglmao

    @xDomglmao

    4 жыл бұрын

    Agree

  • @kaushalendrakumar6705
    @kaushalendrakumar67054 жыл бұрын

    Very good presentation sir My question is why APP is present in neurons because ultimately it get digested by secretase enzymes

  • @manishgupta-ym2xf
    @manishgupta-ym2xf3 жыл бұрын

    Thank you Love from nepal🇳🇵🇳🇵🇳🇵

  • @tahiransari3917
    @tahiransari39175 жыл бұрын

    Sir pls sher more lecture on pathology like leture on orthopadic pathology

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    5 жыл бұрын

    OK. Will do.

  • @sumankashif4291
    @sumankashif42913 жыл бұрын

    Great explanation Sir! However I couldn’t understand what are neurofibrillary tangles exactly? They are bunch of dead neurons or tau protein aggregates?

  • @SAHILGUPTA-nq4ip
    @SAHILGUPTA-nq4ip4 жыл бұрын

    Sir your lectures are very good. But it's a request while recording a lecture do keep mic little bit close to mouth as your voice is low comparatively, it's just a request and suggestion. 🙏

  • @ahmadkhanabro6216
    @ahmadkhanabro62166 жыл бұрын

    so nice

  • @vivekgupta4025
    @vivekgupta40258 жыл бұрын

    why there is a difference between the direction of senile plaqs nd tangles??? kindly let me know sir.

  • @themoreyouknow585
    @themoreyouknow5853 жыл бұрын

    Excellent explanation Respect from Pakistan

  • @nagyadav4751
    @nagyadav47517 жыл бұрын

    thanq sir nice presentation & can we have an other presentation on MALARIAL AGENTS

  • @sushilsingh5194
    @sushilsingh51944 жыл бұрын

    Sir plz explain extrapyramidal side effects tpoic

  • @ansujoy5363
    @ansujoy53633 жыл бұрын

    Sir. How does alcohol, smoking and other environmental factors causes pathophysiology of AD

  • @ramesh123443
    @ramesh1234436 жыл бұрын

    Does Beta amyloid Protein is lipo-protein, if yes what is the lipid part in this. Secondly, how the amyloid proteins are pulled out and deposited as senile plaques means what would be the mechanism for coming out and deposited externally as senile (amyloid) plaques.

  • @amac5455
    @amac54555 жыл бұрын

    Thank You, Sir. This is so important to explain people, what Alzheimer disease is from the basic. My dad is 68yo and he has it. I noticed his memory loss before he was 40!!! I think that people may be born with this disease (??????) My dad had always problem to remember things: important dates, names, to understand things about retirement for example, which were obvious, sometimes he couldn't find right word to explain somenting simple, there were learning dificulties as well. I write from small village in Poland and we don't have many information here about this disease.

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    5 жыл бұрын

    Sorry to hear about your dad. Glad that the lecture is useful. Hope he recovers.

  • @Yeediatable
    @Yeediatable6 жыл бұрын

    Another point....the focus of the camera should be right on the board so that students can have a closer look at what is being written/drawn....sorry...I'm going to lecture on neurodegenerative diseases and am watching these videos for tips...:\...

  • @israrali2329
    @israrali23296 жыл бұрын

    Sir please upload diabetes types and management lectures please ...soon,

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    6 жыл бұрын

    These are already on drbeen.com. Please check there.

  • @clichayed97
    @clichayed976 жыл бұрын

    Helpful lecture, but do you mean INSIDIOUS at @0:49 ?

  • @Drshashikantsk
    @Drshashikantsk3 жыл бұрын

    "Neuroplasticity" we need to work on this by Integrative Medicine Concept.God Bless You all

  • @saulsavelis575
    @saulsavelis5754 жыл бұрын

    ApoE4 code beta or gamma secretase?

  • @jyotidhaundiyal1339
    @jyotidhaundiyal13395 жыл бұрын

    Sir i have a query that is why Alzheimer's disease develop first in hippocampus region ????

  • @ramesh123443
    @ramesh1234436 жыл бұрын

    Is it hyper polarization or hyper phosphorylation and does Tau is the integral part of micro-tubules.

  • @neurosurgerypassion2139

    @neurosurgerypassion2139

    5 жыл бұрын

    Ramesh Kandimalla hyper polarization

  • @Yeediatable
    @Yeediatable6 жыл бұрын

    Sorry...good lecture....but it seems the lecturer has mistakenly written recurrent functions instead of recurrent infections.....

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    6 жыл бұрын

    Good catch. I wrote function instead of infection.

  • @israrali2329
    @israrali23296 жыл бұрын

    Sir upto yet lecture is not uploaded of diabetes management ...and sir u promise to me that I will upload it soon....plz upload sir.

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    6 жыл бұрын

    Diabetes lectures are on drbeen.com.

  • @tahiransari3917
    @tahiransari39175 жыл бұрын

    Sir asalamualaikum myself dr tahir ansari from gsvm medical college kanpur up india & my view for your lecture that your lecture erase my false concept about plage nad tau protein jajakkallah sir ji

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    5 жыл бұрын

    Thank you dear for your note. I am happy that this important concept is cleared. Study well and be a great doctor. My work and my best wishes are with you.

  • @120mdyousufsk
    @120mdyousufsk5 жыл бұрын

    Sir, then how to prevent this abnormal process of Aβ.., is there any relevant solution present.., ?? or after the detection of AD what are those processes to follow for the cure..., I am a research scholar and I'm working on the biosensor part to detect AD. I'm a physics student and I don't know much of the biological activities of AD. but then this lecture helps me a lot.., so thank you so much for the valuable lecture. It is surely a beneficent one for me!! Thank You so much, Sir!!!

  • @Pankaj_84_
    @Pankaj_84_5 жыл бұрын

    Plzz sir make short time vedio

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    5 жыл бұрын

    Have you watched our latest short videos?

  • @honeyleenbalasbas7759
    @honeyleenbalasbas77596 жыл бұрын

    What causes the beta secretase to be more activated than the alpha?

  • @themonkeyminds7252

    @themonkeyminds7252

    6 жыл бұрын

    Honeyleen Balasbas hi !

  • @israrali2329
    @israrali23296 жыл бұрын

    Sir I want free lecture of diabetes... And there need balance .

  • @courtneykloske4417
    @courtneykloske44175 жыл бұрын

    Great lecture! One comment however. ApoE4 does not guarantee Alzheimer's disease. It is a strong genetic risk factor that has been shown to contribute to virtually all aspects of AD. However, a patient can die with ApoE4 and not have been diagnosed with AD or show symptoms of AD. Additionally, the data linking ApoE4 to gamma secretase is lacking in the recent literature. Also, SORL1 is a genetic risk factor not a cause for AD.

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    5 жыл бұрын

    Thank you for adding value for our viewers :-)

  • @sreekarreddy9623
    @sreekarreddy96236 жыл бұрын

    Are you Dr.Najeeb's brother?

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    6 жыл бұрын

    Yes. I am his younger brother :-)

  • @sreekarreddy9623

    @sreekarreddy9623

    6 жыл бұрын

    Drbeen Medical Lectures You taught Alzheimer's disease extremely well. Thank you!

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    6 жыл бұрын

    Good to know. Thank you for your feedback.

  • @cloud1060
    @cloud10607 жыл бұрын

    why Alzheimer's disease starts in the hippocampus?

  • @DrBeenMedicalLectures

    @DrBeenMedicalLectures

    7 жыл бұрын

    Review the lecture :-)

  • @ramjibanyadav7254
    @ramjibanyadav72548 жыл бұрын

    sir leecture is nice but try to make more intractive ,,,its seems littlebit boring

  • @dannythomson8123

    @dannythomson8123

    7 жыл бұрын

    I disagree, it gives you time to follow better. The presentation is still interesting.

  • @kishwarbanotelar3282

    @kishwarbanotelar3282

    6 жыл бұрын

    then watch songs may be you will find the entertainment..

  • @Kevin-dl8oc

    @Kevin-dl8oc

    6 жыл бұрын

    yeah if only someone could make alzheimer's FUN!!