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ALPINE: Zanubrutinib vs Ibrutinib Non-Inferiority Trial with BIG PFS Win: Can u hang your hat on it?

Vinay Prasad, MD MPH; Physician & Professor
Hematologist/ Oncologist
Professor of Epidemiology, Biostatistics and Medicine
Author of 450+ Peer Reviewed papers, 2 Books, 2 Podcasts, 100+ op-eds.
If you want to contact me, do it here: www.vinayakkpra...
Google Scholar: scholar.google...
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Personal Website: www.vinayakkprasad.com
Laboratory Website: www.vkprasadlab.com
Podcast Website: www.plenarysessionpodcast.com
Academic Publications: www.vinayakkpra...
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Twitter @vprasadmdmph

Пікірлер: 39

  • @jess3591
    @jess3591 Жыл бұрын

    Thank you for doing the job our public health regulatory institutions refuse to do. If I'm unfortunate enough to get cancer in my future, I at least have one question to help me vet the oncologist I choose: do you follow the work of Dr. Vinay Prasad?

  • @kathybrady4033

    @kathybrady4033

    Жыл бұрын

    Or better yet, may I please have the soonest possible appointment with Dr. Prasad? And don’t take No for an answer. Happy holidays!!!

  • @VINAYPRASADMDMPH

    @VINAYPRASADMDMPH

    Жыл бұрын

    ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅

  • @mooselodge3881
    @mooselodge3881 Жыл бұрын

    Merry Christmas! Thank you for all you do! ❤

  • @VINAYPRASADMDMPH

    @VINAYPRASADMDMPH

    Жыл бұрын

    ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅

  • @Ralph_Baric_PhD_C2019
    @Ralph_Baric_PhD_C2019 Жыл бұрын

    Merry Christmas, Doc, from a Sunny summer Christmas day Down under in Australia.

  • @VINAYPRASADMDMPH

    @VINAYPRASADMDMPH

    Жыл бұрын

    ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ✌🏻. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅

  • @marchhair01
    @marchhair01 Жыл бұрын

    Dr Prasad is at the top of must watch videos. The only thing I asked for for Christmas was Malignant. Hope it’s in my stocking!

  • @VINAYPRASADMDMPH

    @VINAYPRASADMDMPH

    Жыл бұрын

    ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅

  • @westfield90
    @westfield90 Жыл бұрын

    Merry Christmas doctor. You have been one of the bright lights this year

  • @VINAYPRASADMDMPH

    @VINAYPRASADMDMPH

    Жыл бұрын

    ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅

  • @oldmango8606
    @oldmango8606 Жыл бұрын

    appreciate your time, thoughts and efforts. thanx

  • @VINAYPRASADMDMPH

    @VINAYPRASADMDMPH

    Жыл бұрын

    ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅

  • @pampeters8404
    @pampeters8404 Жыл бұрын

    Merry Christmas from Roatan, Honduras.........my Christmas Eve geek session, thanks for your analysis!!

  • @VINAYPRASADMDMPH

    @VINAYPRASADMDMPH

    Жыл бұрын

    ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅

  • @wisenber
    @wisenber Жыл бұрын

    As a friend of someone on Ibrutinib for two years following an initial treatment of Rituximab, I appreciate your take. I've been wondering why SFN hasn't been studied more in relation to BTK interactions, but I guess there's little money to be made in that.

  • @VINAYPRASADMDMPH

    @VINAYPRASADMDMPH

    Жыл бұрын

    ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅

  • @patrickboland1021
    @patrickboland1021 Жыл бұрын

    I’ve been looking for criticism of this paper for ages, partly because it was unclear why zanubrutinib would succeed where acala failed… very helpful in informing practice

  • @denisekruczyk6847
    @denisekruczyk6847 Жыл бұрын

    Lived your satire on unvax losing teeth and toes. My family got a chuckle out of it, then realized many are to dumb to realize what satire is

  • @VINAYPRASADMDMPH

    @VINAYPRASADMDMPH

    Жыл бұрын

    ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅

  • @ab-mv5mq

    @ab-mv5mq

    Жыл бұрын

    Many are too dumb to write 'too', too.

  • @Soundsaboutright42
    @Soundsaboutright42 Жыл бұрын

    1000 years from now they will say that, and do the opposite... Just as we do today. There is a reason history repeats.

  • @VINAYPRASADMDMPH

    @VINAYPRASADMDMPH

    Жыл бұрын

    ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅

  • @cathyburkart9395
    @cathyburkart9395 Жыл бұрын

    Thank you, Prof.

  • @VINAYPRASADMDMPH

    @VINAYPRASADMDMPH

    Жыл бұрын

    ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅

  • @jayhydren
    @jayhydren Жыл бұрын

    I think we need an equivalent outcome study design (which we don’t have statistical tools yet for) with a side effect burden analysis, this would increase options for patients who struggle more than the average patient with intolerable side effects. This could give patients and their doctors more options. Love to talk more about how to make this potentially possible.

  • @joannabusinessaccount7293
    @joannabusinessaccount7293 Жыл бұрын

    I think you need to go be the head of FDA oncology when the current folks retire….

  • @oldschool8292

    @oldschool8292

    Жыл бұрын

    I'll second that.

  • @VINAYPRASADMDMPH

    @VINAYPRASADMDMPH

    Жыл бұрын

    ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅

  • @JCResDoc94
    @JCResDoc94 Жыл бұрын

    *so if you see a signal you like (in real time), you can increase your sensitivity to that fx w a real time gr8ter sample size;* doesnt seem ok. just like excluding sicker pts or poisoning the control to dec toxic sfx signal by cf. can lean a lot of how to con from these, thx! (tho i doubt one would need to try as hard as these ppl do in most cases.) _JC

  • @VINAYPRASADMDMPH

    @VINAYPRASADMDMPH

    Жыл бұрын

    ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅

  • @SeaMower
    @SeaMower Жыл бұрын

    Will VP actually write a letter to NEJM to professionally address the issues he raises, so that we can hear the responses from the authors?

  • @VINAYPRASADMDMPH

    @VINAYPRASADMDMPH

    Жыл бұрын

    ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅

  • @robyndavis3043
    @robyndavis3043 Жыл бұрын

    My father died from CLL in 2017-if his histologist knew of any “cures,” then he could’ve lived till 2018, or 2019

  • @VINAYPRASADMDMPH

    @VINAYPRASADMDMPH

    Жыл бұрын

    ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅

  • @thegamejunkie1
    @thegamejunkie1 Жыл бұрын

    👍

  • @VINAYPRASADMDMPH

    @VINAYPRASADMDMPH

    Жыл бұрын

    ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ✌🏻. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅

  • @sgeorg80
    @sgeorg80 Жыл бұрын

    👍

  • @VINAYPRASADMDMPH

    @VINAYPRASADMDMPH

    Жыл бұрын

    ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ✌🏻. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅

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