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ALPINE: Zanubrutinib vs Ibrutinib Non-Inferiority Trial with BIG PFS Win: Can u hang your hat on it?
Vinay Prasad, MD MPH; Physician & Professor
Hematologist/ Oncologist
Professor of Epidemiology, Biostatistics and Medicine
Author of 450+ Peer Reviewed papers, 2 Books, 2 Podcasts, 100+ op-eds.
If you want to contact me, do it here: www.vinayakkpra...
Google Scholar: scholar.google...
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Personal Website: www.vinayakkprasad.com
Laboratory Website: www.vkprasadlab.com
Podcast Website: www.plenarysessionpodcast.com
Academic Publications: www.vinayakkpra...
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Twitter @vprasadmdmph
Пікірлер: 39
Thank you for doing the job our public health regulatory institutions refuse to do. If I'm unfortunate enough to get cancer in my future, I at least have one question to help me vet the oncologist I choose: do you follow the work of Dr. Vinay Prasad?
@kathybrady4033
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Or better yet, may I please have the soonest possible appointment with Dr. Prasad? And don’t take No for an answer. Happy holidays!!!
@VINAYPRASADMDMPH
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ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅
Merry Christmas! Thank you for all you do! ❤
@VINAYPRASADMDMPH
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ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅
Merry Christmas, Doc, from a Sunny summer Christmas day Down under in Australia.
@VINAYPRASADMDMPH
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ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ✌🏻. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅
Dr Prasad is at the top of must watch videos. The only thing I asked for for Christmas was Malignant. Hope it’s in my stocking!
@VINAYPRASADMDMPH
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ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅
Merry Christmas doctor. You have been one of the bright lights this year
@VINAYPRASADMDMPH
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ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅
appreciate your time, thoughts and efforts. thanx
@VINAYPRASADMDMPH
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ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅
Merry Christmas from Roatan, Honduras.........my Christmas Eve geek session, thanks for your analysis!!
@VINAYPRASADMDMPH
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ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅
As a friend of someone on Ibrutinib for two years following an initial treatment of Rituximab, I appreciate your take. I've been wondering why SFN hasn't been studied more in relation to BTK interactions, but I guess there's little money to be made in that.
@VINAYPRASADMDMPH
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ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅
I’ve been looking for criticism of this paper for ages, partly because it was unclear why zanubrutinib would succeed where acala failed… very helpful in informing practice
Lived your satire on unvax losing teeth and toes. My family got a chuckle out of it, then realized many are to dumb to realize what satire is
@VINAYPRASADMDMPH
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ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅
@ab-mv5mq
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Many are too dumb to write 'too', too.
1000 years from now they will say that, and do the opposite... Just as we do today. There is a reason history repeats.
@VINAYPRASADMDMPH
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ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅
Thank you, Prof.
@VINAYPRASADMDMPH
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ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅
I think we need an equivalent outcome study design (which we don’t have statistical tools yet for) with a side effect burden analysis, this would increase options for patients who struggle more than the average patient with intolerable side effects. This could give patients and their doctors more options. Love to talk more about how to make this potentially possible.
I think you need to go be the head of FDA oncology when the current folks retire….
@oldschool8292
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I'll second that.
@VINAYPRASADMDMPH
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ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅
*so if you see a signal you like (in real time), you can increase your sensitivity to that fx w a real time gr8ter sample size;* doesnt seem ok. just like excluding sicker pts or poisoning the control to dec toxic sfx signal by cf. can lean a lot of how to con from these, thx! (tho i doubt one would need to try as hard as these ppl do in most cases.) _JC
@VINAYPRASADMDMPH
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ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅
Will VP actually write a letter to NEJM to professionally address the issues he raises, so that we can hear the responses from the authors?
@VINAYPRASADMDMPH
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ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅
My father died from CLL in 2017-if his histologist knew of any “cures,” then he could’ve lived till 2018, or 2019
@VINAYPRASADMDMPH
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ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ💚. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅
👍
@VINAYPRASADMDMPH
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ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ✌🏻. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅
👍
@VINAYPRASADMDMPH
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ᵗʰᵃⁿᵏˢ ᶠᵒʳ ʸᵒᵘʳ ᶠᵉᵉᵈᵇᵃᶜᵏ✌🏻. ᵏⁱⁿᵈˡʸ ʷʳⁱᵗᵉ ᵐᵉ ᵒⁿ ʷʰᵃᵗˢᵃᵖᵖ☛⟊➀➇➂➁➂ꉻ➃➂➃➄➅