Acid base balance - general concept and mechanism
Mechanism of regulation
First line of defence- Blood buffers
1. Bicarbonate
2. Phosphate
3. Protein
Second line of defence -Respiratory regulation
1. Hypoventilation
2. Hyperventilation
Third line of defence - Renal mechanism
1. Excretion of H+
2. Conservation of HCO3-
3. Excretion of titrable acid
4. Excretion of ammonium ions
Bicarbonate buffer
Major buffer in ECF
Bicarbonate: carbonic acid in a ratio of 20:1
pKa-6.1
It is main buffer system because
a. High HCO3 -concentration
b. Components are under physiological control, CO2 by lungs and HCO3- by kidneys
Phosphate buffer
Major intracellular buffer
Na2HPO4: NaH2PO4 in a ratio of 4
pKa-6.8
More potent because pKa value is nearer to the body pH
Protein buffers
Hemoglobin
Albumin
Imidazole group of histidine is the most effective contributor in this buffer system
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@troyeakb6314
2 жыл бұрын
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@shesha4522
2 жыл бұрын
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2 жыл бұрын
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2 жыл бұрын
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2 жыл бұрын
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@idekadimassramava3535
3 жыл бұрын
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@drs.p.vashistha1850
3 жыл бұрын
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@umaimamahboob5081
4 ай бұрын
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@jananiprabhakar2808
Жыл бұрын
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@ankuranurag7987
3 жыл бұрын
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@sandeshtiwari1687
3 жыл бұрын
ka bata ho ?
@cosmosaspacetimeodyssey820
3 жыл бұрын
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@sandeshtiwari1687
3 жыл бұрын
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@user-qi7qm4oy7z
3 жыл бұрын
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@KHANMOHAMMADNAZMUL
3 жыл бұрын
সহজ বাংলায় ও প্রানবন্ত আলোচনার মাধ্যমে কার্ডিওভাস্কুলার ফজিওলজি সহ,অন্যান টপিক্স এর মেডিকেল লেকচার পেতে,সাবস্ক্রাইবঃ kzread.info/dron/38rB9jAXc0eQ5-87iOqEXw.html বি.দ্রঃচ্যানেলটি একদমই নতুন।নিয়মিত ভিডিও পেতে,সাবসক্রাইব করে,বেল আইকনটি বাজিয়ে দিন!
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@Rajesh_Jambhulkar
5 жыл бұрын
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@sangamesh.s8951
7 ай бұрын
Which clg
@eshitaparvin8779
7 ай бұрын
Kpc medical College and hospital in Kolkata, I'm from West Bengal
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Thank you sir well explained