Acid base balance - general concept and mechanism

Mechanism of regulation
First line of defence- Blood buffers
1. Bicarbonate
2. Phosphate
3. Protein
Second line of defence -Respiratory regulation
1. Hypoventilation
2. Hyperventilation
Third line of defence - Renal mechanism
1. Excretion of H+
2. Conservation of HCO3-
3. Excretion of titrable acid
4. Excretion of ammonium ions
Bicarbonate buffer
Major buffer in ECF
Bicarbonate: carbonic acid in a ratio of 20:1
pKa-6.1
It is main buffer system because
a. High HCO3 -concentration
b. Components are under physiological control, CO2 by lungs and HCO3- by kidneys
Phosphate buffer
Major intracellular buffer
Na2HPO4: NaH2PO4 in a ratio of 4
pKa-6.8
More potent because pKa value is nearer to the body pH
Protein buffers
Hemoglobin
Albumin
Imidazole group of histidine is the most effective contributor in this buffer system

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    3 жыл бұрын

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    @jananiprabhakar2808

    Жыл бұрын

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    @rishitdas52073 жыл бұрын

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    @ankuranurag7987

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    @cosmosaspacetimeodyssey820

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    3 жыл бұрын

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    @Vaasu__Hope73 ай бұрын

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    @pallavinaykumar129 ай бұрын

    It did help a lot !!

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    @rojalinstatustime7126 Жыл бұрын

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    @Rajesh_Jambhulkar

    5 жыл бұрын

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    @MedicalInformationjay4 жыл бұрын

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    @abhirathod46893 жыл бұрын

    Thank you sir !!

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    @maheshbansode53913 жыл бұрын

    very nicely explained sir thanks

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    @saurabharve85944 жыл бұрын

    Sir i am medical student but i never understand this concept ... Thank u so much sir for clearing this concept

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    U r awesome teacher 🙏

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    @manojkumarvishwakarma7152 Жыл бұрын

    Wonderful teaching 🙏🙏

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    Excellent sir mza aa gya

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    Amazing

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    @prajjwalsankle62855 жыл бұрын

    Sir please on free radicals and antioxidants

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    @usmanghazanfar35444 жыл бұрын

    Thanks sir not easy to read this topic from book but u made it easiest May Allah fulfill all ur wishes

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    @NitinSharma-kd1wg Жыл бұрын

    Dhanyawaad sirr....❤️❤️❤️

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    @aranyakdutta133 жыл бұрын

    Happy Teachers day Sir 😎🎉 pranaam

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    @gariprak57044 жыл бұрын

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    Thank.you.so.much.for.your.informative.lecture.

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    @viralpatel41363 жыл бұрын

    Sir thank you for easy tutorial video, can we have video on electrolytes , please.

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    @shafatfarooq69035 жыл бұрын

    Thank you very much sir G... I was very much worried about this topic, but u made it look too easy.... Lots of love.

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    @eshitaparvin87797 ай бұрын

    I'm a Medical Laboratory tecnology student, this lecture is very helpful for me.

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    @sangamesh.s8951

    7 ай бұрын

    Which clg

  • @eshitaparvin8779

    @eshitaparvin8779

    7 ай бұрын

    Kpc medical College and hospital in Kolkata, I'm from West Bengal

  • @rivaldorintu7819
    @rivaldorintu78193 жыл бұрын

    Thanks a lot sir.

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    @minkeshratan25673 жыл бұрын

    Katai zehar 🖤

  • @zakirullah3124
    @zakirullah31242 жыл бұрын

    Thank you 😌

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    @Taba_Saba3 ай бұрын

    Very helpful explanation 😍

  • @mariathambi1409
    @mariathambi14093 жыл бұрын

    Thank you so much sir 🙏🙏

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    @himshafeezharipuronlinelec37274 жыл бұрын

    Informative

  • @jaysiharinarayanan5324
    @jaysiharinarayanan53243 жыл бұрын

    Thank u very much sir....

  • @RamithaRGowda
    @RamithaRGowda3 ай бұрын

    Sir in physiology book they have mentioned for excretion of ammonium ion glutamine to glutamic acid take place proximal convulated tubule

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    @sindhujareddy6394 жыл бұрын

    Thank you so much sir

  • @fathimanajeem2992
    @fathimanajeem29922 жыл бұрын

    Thank you sir well explained