Acetylcholine. ACh
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Discover A Simplified Approach to Master the Complexity of Anatomy with me, Dr. David Morton ... The Noted Anatomist!
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This video tutorial discusses the Acetylcholine also known as ACh.
0:00. Intro to ACh
0:21. What is ACh?
0:41. What neurons release ACh?
1:47. Synthesis of ACh
- 3:05. Hemicholinium
3:31. Storage of ACh
- 5:07. Vesamicol
5:35. Release of ACh
- 6:33. Lambert-Eaton Myasthenic Syndrome (LEMS)
- 7:01. Botulinum Toxin (Botulism; Botox)
8:59. Cholinergic receptors (Nicotinic and Muscarinic)
11:48. Inactivation of ACh
- 13:07. AChE Inhibitors (Organophosphates, Sarin gas)
13:43. In-a-Nutshell
13:49. Acknowledgements
Пікірлер: 140
I had a hard time understanding the process of synthesis and metabolism but this guy saved my life. Clear, easy and fun. Best educational video. Please stay in the educational field. Also, gentle people? you're amazing.
@TheNotedAnatomist
9 ай бұрын
Glad it helped!
my mind is blown. As a student from India I thank you for explaining these concepts so elegantly. Our current education system is corrupted as the intent is not about understanding but memorizing large words due to the pressure of scoring grades. We have so much to learn from how the way you teach
@User-9513
Жыл бұрын
We're all gonna make it brah
Thank you sir, you have made Pharmacology much more easier and understandable. I watched your videos before an exam and i got 95%!!!!!!!!! You're GREAT
He's back!!!! We've missed you! Hope you and your loved ones are safe! Will always cheer for your amazing work!
@TheNotedAnatomist
3 жыл бұрын
Thank-you :)
What a teacher! the best so far. made it very simple and objective. congrats!
This simplified this concept so well! I’m glad I found this video. Great job teaching!
@TheNotedAnatomist
4 күн бұрын
Glad it was helpful!
Mr Handy Anatomist,your lectures are enjoyable and you make them easy to understand,thanks
Very beautifully explained and demonstrated. Just love it. - a Veterinary Student from India.
@TheNotedAnatomist
5 ай бұрын
Thank you very much!
This one video taught me more than a 2-hour lecture about ACh.
voice is very similar to Sal Khan, I thought it was him for a sec haha. Thank you Dr. Morton for your videos. Helps a lot.
@monpetitgarcon
Жыл бұрын
yes I was adamant that it was Sal from Khan academy!!!!!!!!!!
a 2 hour lecture is explanied in14 mins thx a lot doc
Am a student from Uganda,I like uo presentation,they are soo touching and easily understandable
This video has made my concept crystal clear. thanks!
oh you just ease me of my stress, thank you so much and God bless you
Finally legend is back😁
Thnkuhhhhj ❤❤❤❤❤ plz aur topic per bhi bnaye ... Its really worked
One of concept based teaching 🎉🎉🎉 Thank you
@TheNotedAnatomist
Жыл бұрын
It's my pleasure
Great Emma reference! Thank you for this - I've been struggling to understand for my anatomy class and this has clarified a lot for me. Well done!
Amazing! Fantastic! Incredible! Astonishing! Mighty! Better than most of Marvel's superhero movies!
The clinical correlates are very helpful
Omg this is simplified, thank you
The noted anatomist! 😍
@TheNotedAnatomist
3 жыл бұрын
Thanks Leo!
Thank you so much for this wonderful explanation of such complicated topic!!!
Excessive accumulation of acetylcholine (ACh) at the neuromuscular junctions and synapses causes symptoms of both muscarinic and nicotinic toxicity. These include cramps, increased salivation, lacrimation, muscular weakness, paralysis, muscular fasciculation, diarrhea, and blurry vision👍
@toz_dumann
3 жыл бұрын
supposedly it would make moving your eyes harder, right?
@TheNotedAnatomist
3 жыл бұрын
Thanks for your comment ... i am kicking myself that i did not include the mnemonic DUMBBELSS that i usually use to describe symptoms of AChE inhibitor poisoning: Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation of muscle and CNS, Lacrimation, Salivation and Sweating.
@jimmythedog2882
2 жыл бұрын
What are the symptoms of low ACh
@indiciaobscure
2 жыл бұрын
@@jimmythedog2882 look into autonomic dysfunctional illnesses, like POTS.
@jennyfreemantle1925
7 ай бұрын
Several of these symptoms include excess fluid/mucous production therefore I am guessing that a runny nose might also be a symptom. What about sensitivity to light, is that a symptom?
Great presentation! Thank you
This is so crucial for people with MTHFR / Methylation issues (which are often downplayed as "quackery") because without proper synthesis of choline from phosphatidylcholine, there will always be a lack of choline to support ACh synthesis. I have C677T ++ but also an impaired PEMT gene, and whilst MTHFR led me down a path of "Methylfolate is everything" I came to realise that Choline support is huge - especially in my case. So it would appear for me that taking Alpha GPC would bypass the impaired PEMT gene and better support my ACh synthesis, as choline supplements apparently do not cross the BBB as well and phosphatidylcholine requires synthesis (via PEMT) so that's also a no-go (stuck coins in your gumball machine - or rather, lack of coins to begin with! 🤣) I've only been studying this for 8 months with no medical/scientific background, but have so far "cured" my migraines (not 1 after suffering daily for 20yrs) and am now focusing on ADD/ADHD. Great video.
Superb presentation! Thank you!
@TheNotedAnatomist
29 күн бұрын
Thank you too!
Really informative, started to take Alpha-GPC and wanted to know what the hell is Acetylcholine. Don't think any other channel would have explained it so well and interesting.
Your videos are fantastic! Really helping me to consolidate the info for my psychopharmacology course! Thank you!
love your lectures!
Thanks doctor ❤❤ Very great
How I understood this as compared to what I was taught by my prof Thank you sir
Very well explained cleared all my doubts actually I didn't actually got a chance to have one👏🏻
Thank you much. This was so helpful
@TheNotedAnatomist
5 ай бұрын
Glad it was helpful!
Thank you so much this was so helpful!
@TheNotedAnatomist
6 ай бұрын
Glad it was helpful!
This helped me so much! Great discussion
Uploaded this just in time for my muscles course. Thank you it helped so much
@TheNotedAnatomist
3 жыл бұрын
Happy to help!
you are going to rock the field of pharmacology too.
You make really good videos keep it up
@TheNotedAnatomist
3 жыл бұрын
I appreciate it!
Thank you very much for your meaningfull vidios
Excellent lecture 👌
@TheNotedAnatomist
7 ай бұрын
Thanks a lot
This helped me so much. Thanks a lot❤❤
Thank you❤
Great explanation!! Super helpful 😃
THANK YOU SO MUCH
@TheNotedAnatomist
Жыл бұрын
You're welcome!
Thanks allot 😌 dear sir
you are best.may allah gives you more and more
Amazing! 👏
I like the word ching😂😂😂😂
@nathanhaigler8139
2 жыл бұрын
That’s my favorite part 😂
@whirlwind872
Жыл бұрын
SHINGGGGGG!!!
@Poetry15888
Жыл бұрын
I also 🤣🤣🤣
Thank you Dr Morton!
@TheNotedAnatomist
3 жыл бұрын
You're most welcome!
Just what I needed.. Thanks a bunch.
Thank you sir ....
@TheNotedAnatomist
10 ай бұрын
Most welcome
can you please do pharmacology-based videos glad I found your channel ❤
Excellent video thank you so much!!
I mean all respects for Walter white but YOUR THE DANGER 😂🔥
Missed your videos sir.
You. Are. The. Best.
Best ever explained
Sooooooooooooooo GOOOOOD
Great explanation! Thank you, keep it up!
I love you Man❤️
This was so helpful. Thank you
Organophosphates are insecticides, not fertilizers. They have a similar effect on insects to that of nerve gas on humans.
Soo awesome 👌🏻
amazing to say the least
You are a life saver thank you ❤️
amazing video. THANK YOU
Nicely done 👍
@TheNotedAnatomist
3 жыл бұрын
Many Thanks 👍
Great
thank you ❤
thank you
THANK YOU!!!!
Thank u so much..❤❤❤❤
Wow! Just wow! 👏
I want the pdf or PowerPoint and thank you so much 😊
so helpful👍
There are drugs that block acetylcholine to stop sweating. But I wonder if this affects on building muscle & performance. I noticed my muscles have gotten weaker since taking an anticholinergic. Is there a point to even trying to build muscle when acetylcholine is blocked?
awesome sir
Jesus bless you. Thank you!
Does botox completely cure hyperhydrosis
@TheNotedAnatomist
3 жыл бұрын
It does not cure the hyperhydrosis because the body eventually creates more SNARE protein complexes so the nerves release ACh again ... maybe 4-6 months. Then another injection would be recommended.
@karfeishaolyia9567
3 жыл бұрын
@@TheNotedAnatomist oh men i wish it did but anyway love your explanation keep up the good work.
Hi, i got a question, by the way excellent videos, Acetyl CoA can go outside the mitochondria directly or it must be converted to citrate first and then can go out of the mitochondria?
❤❤❤
thank you🥺❤️
The best parts were every time he said "SHINGGGG"
Where can i learn these things?
I was on a low dose anti-cholinergic anti-depressant called clomipramine for 4 years. Now I am off it...to what extent has it negatively impacted my memory...will my memory rebound?
King
@TheNotedAnatomist
3 жыл бұрын
...Blush:)
Ziiiiiing! Love it!
@TheNotedAnatomist
3 жыл бұрын
Yay! Thank you!
Please can acetylcholine be extracted from the neuron or nerve fibre of an animal when they are synthesized?
Why you didnt tell you need B1 Vitamin for synthesis
Shiii...ng 😊 Thumbs up my friends 😇😅
Good
@TheNotedAnatomist
4 ай бұрын
Thanks
Thank you, sir and fuck nervous system
Shing~~⚔️
💚💚💚
Your voice is like Khan Academy hehe
Up
I literally enjoyed this video more than any movie 🥹🫶🫶
@TheNotedAnatomist
4 ай бұрын
Haha thanks
are you also The Thought Emporium guy? wtf, your voice is exactly the same as his
Richard.. is that you?