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Acetylcholine. ACh

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Discover A Simplified Approach to Master the Complexity of Anatomy with me, Dr. David Morton ... The Noted Anatomist!
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This video tutorial discusses the Acetylcholine also known as ACh.
0:00​. Intro to ACh
0:21​. What is ACh?
0:41​. What neurons release ACh?
1:47​. Synthesis of ACh
- 3:05. Hemicholinium
3:31​. Storage of ACh
- 5:07. Vesamicol
5:35​. Release of ACh
- 6:33. Lambert-Eaton Myasthenic Syndrome (LEMS)
- 7:01. Botulinum Toxin (Botulism; Botox)
8:59​. Cholinergic receptors (Nicotinic and Muscarinic)
11:48​. Inactivation of ACh
- 13:07. AChE Inhibitors (Organophosphates, Sarin gas)
13:43​. In-a-Nutshell
13:49​. Acknowledgements

Пікірлер: 140

  • @edwardyun8413
    @edwardyun84139 ай бұрын

    I had a hard time understanding the process of synthesis and metabolism but this guy saved my life. Clear, easy and fun. Best educational video. Please stay in the educational field. Also, gentle people? you're amazing.

  • @TheNotedAnatomist

    @TheNotedAnatomist

    9 ай бұрын

    Glad it helped!

  • @adivasi8277
    @adivasi82772 жыл бұрын

    my mind is blown. As a student from India I thank you for explaining these concepts so elegantly. Our current education system is corrupted as the intent is not about understanding but memorizing large words due to the pressure of scoring grades. We have so much to learn from how the way you teach

  • @User-9513

    @User-9513

    Жыл бұрын

    We're all gonna make it brah

  • @ayahfattal6885
    @ayahfattal68852 жыл бұрын

    Thank you sir, you have made Pharmacology much more easier and understandable. I watched your videos before an exam and i got 95%!!!!!!!!! You're GREAT

  • @Darkklordd77
    @Darkklordd773 жыл бұрын

    He's back!!!! We've missed you! Hope you and your loved ones are safe! Will always cheer for your amazing work!

  • @TheNotedAnatomist

    @TheNotedAnatomist

    3 жыл бұрын

    Thank-you :)

  • @jome2257
    @jome22572 жыл бұрын

    What a teacher! the best so far. made it very simple and objective. congrats!

  • @KerryKarl
    @KerryKarl6 күн бұрын

    This simplified this concept so well! I’m glad I found this video. Great job teaching!

  • @TheNotedAnatomist

    @TheNotedAnatomist

    4 күн бұрын

    Glad it was helpful!

  • @rapstartwagi9397
    @rapstartwagi93972 жыл бұрын

    Mr Handy Anatomist,your lectures are enjoyable and you make them easy to understand,thanks

  • @manaswinisahoo4556
    @manaswinisahoo45565 ай бұрын

    Very beautifully explained and demonstrated. Just love it. - a Veterinary Student from India.

  • @TheNotedAnatomist

    @TheNotedAnatomist

    5 ай бұрын

    Thank you very much!

  • @kavinthegreat
    @kavinthegreat Жыл бұрын

    This one video taught me more than a 2-hour lecture about ACh.

  • @Thekraziesars
    @Thekraziesars3 жыл бұрын

    voice is very similar to Sal Khan, I thought it was him for a sec haha. Thank you Dr. Morton for your videos. Helps a lot.

  • @monpetitgarcon

    @monpetitgarcon

    Жыл бұрын

    yes I was adamant that it was Sal from Khan academy!!!!!!!!!!

  • @ahmedwaly5226
    @ahmedwaly5226 Жыл бұрын

    a 2 hour lecture is explanied in14 mins thx a lot doc

  • @byamukamahamson2294
    @byamukamahamson2294 Жыл бұрын

    Am a student from Uganda,I like uo presentation,they are soo touching and easily understandable

  • @RakeshKumar-ds8zj
    @RakeshKumar-ds8zj2 жыл бұрын

    This video has made my concept crystal clear. thanks!

  • @docsampencilstrokes7874
    @docsampencilstrokes78742 жыл бұрын

    oh you just ease me of my stress, thank you so much and God bless you

  • @ayseakpnar6049
    @ayseakpnar60493 жыл бұрын

    Finally legend is back😁

  • @babitachouhan5201
    @babitachouhan52012 ай бұрын

    Thnkuhhhhj ❤❤❤❤❤ plz aur topic per bhi bnaye ... Its really worked

  • @zishanahmad7089
    @zishanahmad7089 Жыл бұрын

    One of concept based teaching 🎉🎉🎉 Thank you

  • @TheNotedAnatomist

    @TheNotedAnatomist

    Жыл бұрын

    It's my pleasure

  • @traciemitchell1086
    @traciemitchell10863 жыл бұрын

    Great Emma reference! Thank you for this - I've been struggling to understand for my anatomy class and this has clarified a lot for me. Well done!

  • @mariociencia12
    @mariociencia122 жыл бұрын

    Amazing! Fantastic! Incredible! Astonishing! Mighty! Better than most of Marvel's superhero movies!

  • @deedeedeadtree4215
    @deedeedeadtree42152 жыл бұрын

    The clinical correlates are very helpful

  • @WisdomForster-or6yy
    @WisdomForster-or6yy2 ай бұрын

    Omg this is simplified, thank you

  • @leokemie
    @leokemie3 жыл бұрын

    The noted anatomist! 😍

  • @TheNotedAnatomist

    @TheNotedAnatomist

    3 жыл бұрын

    Thanks Leo!

  • @bbnurra
    @bbnurra Жыл бұрын

    Thank you so much for this wonderful explanation of such complicated topic!!!

  • @dailydoseofmedicinee
    @dailydoseofmedicinee3 жыл бұрын

    Excessive accumulation of acetylcholine (ACh) at the neuromuscular junctions and synapses causes symptoms of both muscarinic and nicotinic toxicity. These include cramps, increased salivation, lacrimation, muscular weakness, paralysis, muscular fasciculation, diarrhea, and blurry vision👍

  • @toz_dumann

    @toz_dumann

    3 жыл бұрын

    supposedly it would make moving your eyes harder, right?

  • @TheNotedAnatomist

    @TheNotedAnatomist

    3 жыл бұрын

    Thanks for your comment ... i am kicking myself that i did not include the mnemonic DUMBBELSS that i usually use to describe symptoms of AChE inhibitor poisoning: Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation of muscle and CNS, Lacrimation, Salivation and Sweating.

  • @jimmythedog2882

    @jimmythedog2882

    2 жыл бұрын

    What are the symptoms of low ACh

  • @indiciaobscure

    @indiciaobscure

    2 жыл бұрын

    @@jimmythedog2882 look into autonomic dysfunctional illnesses, like POTS.

  • @jennyfreemantle1925

    @jennyfreemantle1925

    7 ай бұрын

    Several of these symptoms include excess fluid/mucous production therefore I am guessing that a runny nose might also be a symptom. What about sensitivity to light, is that a symptom?

  • @Academia_Signa
    @Academia_Signa4 ай бұрын

    Great presentation! Thank you

  • @Paul-hu1ht
    @Paul-hu1ht26 күн бұрын

    This is so crucial for people with MTHFR / Methylation issues (which are often downplayed as "quackery") because without proper synthesis of choline from phosphatidylcholine, there will always be a lack of choline to support ACh synthesis. I have C677T ++ but also an impaired PEMT gene, and whilst MTHFR led me down a path of "Methylfolate is everything" I came to realise that Choline support is huge - especially in my case. So it would appear for me that taking Alpha GPC would bypass the impaired PEMT gene and better support my ACh synthesis, as choline supplements apparently do not cross the BBB as well and phosphatidylcholine requires synthesis (via PEMT) so that's also a no-go (stuck coins in your gumball machine - or rather, lack of coins to begin with! 🤣) I've only been studying this for 8 months with no medical/scientific background, but have so far "cured" my migraines (not 1 after suffering daily for 20yrs) and am now focusing on ADD/ADHD. Great video.

  • @rudysmith6293
    @rudysmith629329 күн бұрын

    Superb presentation! Thank you!

  • @TheNotedAnatomist

    @TheNotedAnatomist

    29 күн бұрын

    Thank you too!

  • @fatfingersman
    @fatfingersman2 жыл бұрын

    Really informative, started to take Alpha-GPC and wanted to know what the hell is Acetylcholine. Don't think any other channel would have explained it so well and interesting.

  • @user-dc4bc7te1h
    @user-dc4bc7te1h Жыл бұрын

    Your videos are fantastic! Really helping me to consolidate the info for my psychopharmacology course! Thank you!

  • @dogmatix81
    @dogmatix812 ай бұрын

    love your lectures!

  • @rehamkhalidkamal4421
    @rehamkhalidkamal44219 ай бұрын

    Thanks doctor ❤❤ Very great

  • @user-sg3os3lr1v
    @user-sg3os3lr1v6 ай бұрын

    How I understood this as compared to what I was taught by my prof Thank you sir

  • @shaikhmehreen5671
    @shaikhmehreen5671 Жыл бұрын

    Very well explained cleared all my doubts actually I didn't actually got a chance to have one👏🏻

  • @kellymontano992
    @kellymontano9925 ай бұрын

    Thank you much. This was so helpful

  • @TheNotedAnatomist

    @TheNotedAnatomist

    5 ай бұрын

    Glad it was helpful!

  • @Shasharinabina
    @Shasharinabina6 ай бұрын

    Thank you so much this was so helpful!

  • @TheNotedAnatomist

    @TheNotedAnatomist

    6 ай бұрын

    Glad it was helpful!

  • @adrianaescola5996
    @adrianaescola59962 жыл бұрын

    This helped me so much! Great discussion

  • @saltysuga9986
    @saltysuga99863 жыл бұрын

    Uploaded this just in time for my muscles course. Thank you it helped so much

  • @TheNotedAnatomist

    @TheNotedAnatomist

    3 жыл бұрын

    Happy to help!

  • @muhammadyasirkhan7004
    @muhammadyasirkhan70043 жыл бұрын

    you are going to rock the field of pharmacology too.

  • @dranshumansahu6114
    @dranshumansahu61143 жыл бұрын

    You make really good videos keep it up

  • @TheNotedAnatomist

    @TheNotedAnatomist

    3 жыл бұрын

    I appreciate it!

  • @user-we8qp8ji7t
    @user-we8qp8ji7t5 ай бұрын

    Thank you very much for your meaningfull vidios

  • @gaurinimbhorkar8571
    @gaurinimbhorkar85717 ай бұрын

    Excellent lecture 👌

  • @TheNotedAnatomist

    @TheNotedAnatomist

    7 ай бұрын

    Thanks a lot

  • @Rayan-ps9mf
    @Rayan-ps9mf Жыл бұрын

    This helped me so much. Thanks a lot❤❤

  • @Monya17.30
    @Monya17.307 ай бұрын

    Thank you❤

  • @fionabaack3430
    @fionabaack34302 жыл бұрын

    Great explanation!! Super helpful 😃

  • @humaidquresh8434
    @humaidquresh8434 Жыл бұрын

    THANK YOU SO MUCH

  • @TheNotedAnatomist

    @TheNotedAnatomist

    Жыл бұрын

    You're welcome!

  • @Poetry15888
    @Poetry15888 Жыл бұрын

    Thanks allot 😌 dear sir

  • @masudahmed5797
    @masudahmed57976 ай бұрын

    you are best.may allah gives you more and more

  • @leenalsader8476
    @leenalsader84762 жыл бұрын

    Amazing! 👏

  • @montazaraldujeili2475
    @montazaraldujeili24753 жыл бұрын

    I like the word ching😂😂😂😂

  • @nathanhaigler8139

    @nathanhaigler8139

    2 жыл бұрын

    That’s my favorite part 😂

  • @whirlwind872

    @whirlwind872

    Жыл бұрын

    SHINGGGGGG!!!

  • @Poetry15888

    @Poetry15888

    Жыл бұрын

    I also 🤣🤣🤣

  • @Mayowababs
    @Mayowababs3 жыл бұрын

    Thank you Dr Morton!

  • @TheNotedAnatomist

    @TheNotedAnatomist

    3 жыл бұрын

    You're most welcome!

  • @patiencesimatele5
    @patiencesimatele53 жыл бұрын

    Just what I needed.. Thanks a bunch.

  • @sushmitanayak6194
    @sushmitanayak619410 ай бұрын

    Thank you sir ....

  • @TheNotedAnatomist

    @TheNotedAnatomist

    10 ай бұрын

    Most welcome

  • @voonalachimolala6984
    @voonalachimolala6984 Жыл бұрын

    can you please do pharmacology-based videos glad I found your channel ❤

  • @elanas6024
    @elanas60242 жыл бұрын

    Excellent video thank you so much!!

  • @l_a_4k
    @l_a_4k Жыл бұрын

    I mean all respects for Walter white but YOUR THE DANGER 😂🔥

  • @GaneshKumar-pm4fl
    @GaneshKumar-pm4fl3 жыл бұрын

    Missed your videos sir.

  • @Userhandle7384
    @Userhandle73842 жыл бұрын

    You. Are. The. Best.

  • @tanaytejus5726
    @tanaytejus57262 жыл бұрын

    Best ever explained

  • @BruceWayne-ks7ct
    @BruceWayne-ks7ct3 ай бұрын

    Sooooooooooooooo GOOOOOD

  • @daniamorouj
    @daniamorouj2 жыл бұрын

    Great explanation! Thank you, keep it up!

  • @user-yj6nb2xl3g
    @user-yj6nb2xl3g3 жыл бұрын

    I love you Man❤️

  • @coveredbygrace8241
    @coveredbygrace82413 жыл бұрын

    This was so helpful. Thank you

  • @DisabilityExams
    @DisabilityExams3 жыл бұрын

    Organophosphates are insecticides, not fertilizers. They have a similar effect on insects to that of nerve gas on humans.

  • @mercydeogratius
    @mercydeogratius Жыл бұрын

    Soo awesome 👌🏻

  • @Joe-sr2pm
    @Joe-sr2pm3 жыл бұрын

    amazing to say the least

  • @user-ir5jm4vv1b
    @user-ir5jm4vv1b2 жыл бұрын

    You are a life saver thank you ❤️

  • @monkehp
    @monkehp3 жыл бұрын

    amazing video. THANK YOU

  • @LearningAnatomysaqib
    @LearningAnatomysaqib3 жыл бұрын

    Nicely done 👍

  • @TheNotedAnatomist

    @TheNotedAnatomist

    3 жыл бұрын

    Many Thanks 👍

  • @drabdirahmansaladibrahim4602
    @drabdirahmansaladibrahim4602 Жыл бұрын

    Great

  • @ahmadababneh4772
    @ahmadababneh4772 Жыл бұрын

    thank you ❤

  • @Nouna0804
    @Nouna08043 жыл бұрын

    thank you

  • @adrianaescola5996
    @adrianaescola59962 жыл бұрын

    THANK YOU!!!!

  • @indirajithm3325
    @indirajithm3325 Жыл бұрын

    Thank u so much..❤❤❤❤

  • @hamzahdomeih7750
    @hamzahdomeih7750 Жыл бұрын

    Wow! Just wow! 👏

  • @user-vz4wo2mh4e
    @user-vz4wo2mh4e Жыл бұрын

    I want the pdf or PowerPoint and thank you so much 😊

  • @rosemarymwaluko751
    @rosemarymwaluko7512 жыл бұрын

    so helpful👍

  • @OiVinn-eq1ml
    @OiVinn-eq1ml Жыл бұрын

    There are drugs that block acetylcholine to stop sweating. But I wonder if this affects on building muscle & performance. I noticed my muscles have gotten weaker since taking an anticholinergic. Is there a point to even trying to build muscle when acetylcholine is blocked?

  • @juhimondal3004
    @juhimondal30043 жыл бұрын

    awesome sir

  • @atunechinaza1575
    @atunechinaza15756 ай бұрын

    Jesus bless you. Thank you!

  • @karfeishaolyia9567
    @karfeishaolyia95673 жыл бұрын

    Does botox completely cure hyperhydrosis

  • @TheNotedAnatomist

    @TheNotedAnatomist

    3 жыл бұрын

    It does not cure the hyperhydrosis because the body eventually creates more SNARE protein complexes so the nerves release ACh again ... maybe 4-6 months. Then another injection would be recommended.

  • @karfeishaolyia9567

    @karfeishaolyia9567

    3 жыл бұрын

    @@TheNotedAnatomist oh men i wish it did but anyway love your explanation keep up the good work.

  • @camilodelacruz1311
    @camilodelacruz1311 Жыл бұрын

    Hi, i got a question, by the way excellent videos, Acetyl CoA can go outside the mitochondria directly or it must be converted to citrate first and then can go out of the mitochondria?

  • @braveheart6069
    @braveheart6069 Жыл бұрын

    ❤❤❤

  • @shriyajagadam9567
    @shriyajagadam95673 жыл бұрын

    thank you🥺❤️

  • @gamma701
    @gamma7012 жыл бұрын

    The best parts were every time he said "SHINGGGG"

  • @kostaborojevic498
    @kostaborojevic498 Жыл бұрын

    Where can i learn these things?

  • @b-23aryankishore64
    @b-23aryankishore642 жыл бұрын

    I was on a low dose anti-cholinergic anti-depressant called clomipramine for 4 years. Now I am off it...to what extent has it negatively impacted my memory...will my memory rebound?

  • @anaisnintuition
    @anaisnintuition3 жыл бұрын

    King

  • @TheNotedAnatomist

    @TheNotedAnatomist

    3 жыл бұрын

    ...Blush:)

  • @theclassroomdoc
    @theclassroomdoc3 жыл бұрын

    Ziiiiiing! Love it!

  • @TheNotedAnatomist

    @TheNotedAnatomist

    3 жыл бұрын

    Yay! Thank you!

  • @gaiuschannel8819
    @gaiuschannel88192 жыл бұрын

    Please can acetylcholine be extracted from the neuron or nerve fibre of an animal when they are synthesized?

  • @voiceofreason1829
    @voiceofreason1829 Жыл бұрын

    Why you didnt tell you need B1 Vitamin for synthesis

  • @73Katerchen
    @73Katerchen Жыл бұрын

    Shiii...ng 😊 Thumbs up my friends 😇😅

  • @drabdirahmansaladibrahim4602
    @drabdirahmansaladibrahim46024 ай бұрын

    Good

  • @TheNotedAnatomist

    @TheNotedAnatomist

    4 ай бұрын

    Thanks

  • @e.mohamed1808
    @e.mohamed18089 ай бұрын

    Thank you, sir and fuck nervous system

  • @yejun6884
    @yejun68842 жыл бұрын

    Shing~~⚔️

  • @Emad_22.
    @Emad_22. Жыл бұрын

    💚💚💚

  • @nicoleignacio3559
    @nicoleignacio35593 жыл бұрын

    Your voice is like Khan Academy hehe

  • @viswanathan6810
    @viswanathan68107 ай бұрын

    Up

  • @amanix18
    @amanix184 ай бұрын

    I literally enjoyed this video more than any movie 🥹🫶🫶

  • @TheNotedAnatomist

    @TheNotedAnatomist

    4 ай бұрын

    Haha thanks

  • @Ewr42
    @Ewr422 жыл бұрын

    are you also The Thought Emporium guy? wtf, your voice is exactly the same as his

  • @DocJabin
    @DocJabin7 ай бұрын

    Richard.. is that you?