When and how to prescribe triple antithrombotic therapy?
Can we shorten the duration of DAPT, and do we need to prolong beyond 1 year in some patients?
Let's elaborate these questions and answers in this interesting video.
0:00 Triple Antithrombotic Therapy
12:24 Alternative Antiplatelet Strategies
23:37 Strategies to reduce bleedi ng during PCI
25:12 Antithrombotics in conservatively treated patients
2023 ESC Guidelines for the Management of Acute Coronary Syndromes
www.escardio.org/Guidelines/C...
2023 ESC Guidelines for the management of acute coronary syndromes Supplementary data
oup.silverchair-cdn.com/oup/b...
RE-DUAL PCI trial. Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation
www.nejm.org/doi/full/10.1056...
PIONEER AF-PCI trial. Prevention of Bleeding in Patients with Atrial Fibrillation Undergoing PCI
www.nejm.org/doi/full/10.1056...
AUGUSTUS trial. Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation
www.nejm.org/doi/full/10.1056...
ENTRUST-AF PCI trial. Edoxaban-based versus vitamin K antagonist-based antithrombotic regimen after successful coronary stenting in patients with atrial fibrillation
pubmed.ncbi.nlm.nih.gov/31492...
STOPDAPT-2-ACS trial. Comparison of Clopidogrel Monotherapy After 1 to 2 Months of Dual Antiplatelet Therapy With 12 Months of Dual Antiplatelet Therapy in Patients With Acute Coronary Syndrome
jamanetwork.com/journals/jama...
TWILIGHT trial. Ticagrelor with or without Aspirin in High-Risk Patients after PCI
www.nejm.org/doi/full/10.1056...
TICO trial. Effect of Ticagrelor Monotherapy vs Ticagrelor With Aspirin on Major Bleeding and Cardiovascular Events in Patients With Acute Coronary Syndrome
jamanetwork.com/journals/jama...
TOPIC trial. Benefit of switching dual antiplatelet therapy after acute coronary syndrome (timing of platelet inhibition after acute coronary syndrome)
pubmed.ncbi.nlm.nih.gov/28510...
COMPASS trial. Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease
www.nejm.org/doi/full/10.1056...
PEGASUS-TIMI 54 trial. Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction
www.nejm.org/doi/full/10.1056...