>Sleep deprivation kills >me watching this at 2am >oh

@jaromgregson8923

3 жыл бұрын

Literally came to comment this at 2am

@yellowspike3344

3 жыл бұрын

eh ur fine unless u sleep at 2am and have to wake up early.

@silic8873

3 жыл бұрын

me at 4 a.m ...

@vozestoica8436

3 жыл бұрын

I can't sleeeeeeepppp

@anupneupane6620

3 жыл бұрын

I was thinking about the same thing

Awesome! Providing links to these important discoveries would be very much helpful and easy just to gain more idea on this. Thanks

@RameshChaudhary-zd5ch

3 жыл бұрын

Wow I'm gonna sleep now 🤪

@twonumber22

3 жыл бұрын

@Anime SucksIt triggered you for some strange reason.

@patrickwinther

3 жыл бұрын

Insane that this have not been done :o

@BiBoetzke

3 жыл бұрын

Yeah I'd love to take a look at those papers

@twonumber22

3 жыл бұрын

@@BiBoetzke Probably paywalled. :/

When your brain is trying to understand itself

@okStevie

3 жыл бұрын

You made me say “oh my god, so true” out loud, congrats.

@KessieCS

3 жыл бұрын

@Social Justice Warrior You are aware the brain is the person ... right?

@miko5167

3 жыл бұрын

@Social Justice Warrior What is the person in your point of view?

@miko5167

3 жыл бұрын

@Social Justice Warrior Sounds like you're using philosophy to prove you're point even though evidence suggests that the brain is the person. All cognitive processes happen in the brain. The brain processses all information our body collects, controls all body functions and makes all decisions. Sure we need arms for example but those are also controlled by the brain. We are who we are even without any limbs but if you remove the brain, no system in our body can continue functioning.

@BlueMacGyver

3 жыл бұрын

@Social Justice Warrior You must admit there isn't much need for philosophy until you get to the limiting of science by law or morals. The heart of the comment is a scientific revelation and one of humor I think.

My year's biggest breakthrough was to follow the Sean Carroll's advice to read Quanta Magazine. Thank you for all your great work! We really appreciate it.

@SahilP2648

3 жыл бұрын

Watch Sir Roger Penrose's Orc OR theory about consciousness in Lex Fridman's channel

@GabrielFuentesOficial

3 жыл бұрын

@@SahilP2648 I will! :)

@fuzzydark1395

3 жыл бұрын

THIS is what we need, not that Ray Mak bs

@aliqureshi9741

3 жыл бұрын

FuzzyDark xD

@ant0_alwin

3 жыл бұрын

@@SahilP2648 thank you my mahn I have no idea why ive been sleeping on such a huge huge thing this is the sorta stuff that keeps you awake at night thinking thank you these theories connect so beautifully

"The brain is the most advanced machine in the universe" - Brain said

@EdgarGarcia-li2jz

3 жыл бұрын

It's not our brains saying that, it's the tools at out disposal measuring the brains capacity for information processing.

@maxwilson7001

3 жыл бұрын

Hahahahahaha

@sarahkay4765

3 жыл бұрын

I imagine the Obama medal meme here

@goldenwarrior1186

3 жыл бұрын

@@EdgarGarcia-li2jz that our brains are processing

@sammysaito529

2 жыл бұрын

@@EdgarGarcia-li2jz which mean by proxy the brain is saying that

i always wondered why my stomach felt weird when i had less sleep apparently i was dying

@gotaro69

2 жыл бұрын

R.I.P

The biggest discovery for me was Dragana's hair.

@mikaelsjoberg1894

3 жыл бұрын

Yes, a Trump/Maga supporter for sure!!!

@aubade_1

3 жыл бұрын

@@mikaelsjoberg1894 what?

@doriannamjesnik3007

3 жыл бұрын

@@aubade_1 trying to get political smh.

@karolkunysz9205

3 жыл бұрын

you're brutal bro xDD

@S3Mi87

3 жыл бұрын

@@mikaelsjoberg1894 TDS for sure. Ps. Funny how the only SJW coloured hair person in the video had to mention that their research is performed in a "non-biased manner", like all other researches are biased by default. Virtue signalling much?

Holy crap watching this at 1 am and that last one scared me. Good night!!

@okStevie

3 жыл бұрын

1 AM isn’t too bad, as long as you get your 8 hours you should be good.

@jeyaramsathees6128

3 жыл бұрын

Rip

@solcoster8110

3 жыл бұрын

people can stay awake for ages Its not like ur suddenly gonna die

@PcPx211

3 жыл бұрын

1am? pffff chronic insomnia without a Benzo or Zopiclone script, that's were it's at 👌

@Gob.

2 жыл бұрын

@@okStevie you really only need 6

That last one hits hard. Imagine if we could quantify the negative health effects of sleep deprivation. How many people would stop neglecting their sleep needs if they knew precisely how much damage sleep deprivation does?

@fullmetal783

2 жыл бұрын

When one is going thru sleep deprivation, I believe there is a point, a maxima if you will, where cognition is somewhat enhanced. I’ve felt wired and inspired many a time. Doesn’t last and the crash isn’t worth it

@FieryRedDonkeyOfHell

2 жыл бұрын

@@fullmetal783 I've felt that too. Like a second wind. Feels awesome, but the second crash that follows is too much.

@azmard4865

2 жыл бұрын

@@FieryRedDonkeyOfHell can you explain it in layman's term hehehe

@sgtmayhem7567

2 жыл бұрын

There would still be a significant number of people who wouldn’t change their habits even if they knew, look at alcoholics, drug addicts and even those who still smoke a pack a day.

@hsoldacct2905

2 жыл бұрын

@@azmard4865 lmao that was laymen’s terms

When that biologist mentioned "An individual is a process" I felt that.

@georgeniculescu

3 жыл бұрын

we are merely a projection of many processes, which itself is a process.

@dog-ez2nu

3 жыл бұрын

Poetic. I always love the analogy that all life is super sophisticated biomechanical robots and that what makes 'us' is the order and likelihood of certain chemical reactions and diffusions, that's trippy to me.

@darthgandalf9485

3 жыл бұрын

@@dog-ez2nu you may like thomas hobbes then

@ashleylaw

3 жыл бұрын

Yes a point of interest. being saying this for years now. And the man was right it is 'information' .

@ItachiXSanjii

3 жыл бұрын

So its confirmed that we truly are trapped inside some matrix.

I’m surprised the AI protein folding breakthrough didn’t make it to the video.

@alanh.790

3 жыл бұрын

That's because it is not a breakthrough. Prediction of protein folding at an individual protein level is not biologically meaningful. Proteins in reality interact with many other proteins, and also many proteins contain intrinsically disordered regions which can form more stable structure upon interactions. Additionally, many proteins undergo modifications. Protein structure determination still requires experimental validation. There is bias in algorithms that predict structures because they use a library of known structures, and thus fail in the case of new motifs/folds.

@rainofficial1924

3 жыл бұрын

@@alanh.790 artificial intelligence uses existing data as its teacher, that is true. But it can also be told to go wild and do what it hasn't seen. But again, you are right in a way because in order to do this imagination process in a meaningfull and applicable way it needs to learn much more about molecular bonds, protein structures, cell conditions. But it isn't imposible. Just not ready yet

@alanh.790

3 жыл бұрын

@@grapesurgeon yes, but protein Structure databases already suffer from human errors and bias. In this case, you feed the algorithm garbage and end up with garbage. We need a more fundamental (physical) understanding of protein structure rather than prediction algorithms.

Just found this channel. Absolutely blown away with the presentation quality. Gonna binge this channel for Christmas break.

That sleep deprivation scared me since i'm feeling sleepy rn

@michelepellegrino6640

3 жыл бұрын

it's a long term effect so you don't have to worry if sometimes it happens. That said, take a nap during the day if you feel sleepy, it will for sure help

@ArawnOfAnnwn

3 жыл бұрын

You'll never be able to actually do that. Your body won't let you. Even sleep deprivation torture requires constant oversight by the torturers. There are people who've been global circumnavigations in balloons who've wound up sleep deprived and almost fallen out of the sky just cos they were unable to stay awake. Regardless of how uncomfortable you are, your body won't let you go without sleep for more than a few days - and it takes a week or more of deprivation for it to actually start dying.

So happy you've invested in good graphics people to create visual analogy to your writing. Often after seeing a supporting graphic do I say, "Ah, I SEE what you mean."

Sad to see Yauncheng Lu's epigenetic reprogramming paper not mentioned here :(

@mitziodelarge

3 жыл бұрын

Whats that? got the link or some article?

@david_junior

3 жыл бұрын

I second your comment @@mitziodelarge

@RazvanNemes

3 жыл бұрын

@@mitziodelarge I'd like to introduce you to Google.

@phamthohongduong

3 жыл бұрын

@@RazvanNemes kinda lazy for people who purposefully mentioned something significant was omitted 🤷🏽‍♂️

@92conan

3 жыл бұрын

Thanks for letting me know of this grounbreaking study @FortNite King

How have I only discovered this channel today when I spend hours each day learning an infinite amount on KZread? I can't answer that but I am seriously grateful I did. These are the kinds of issues I am most interested in, finding factual discoveries of what probably makes things work, from a nano level to a universe sized level. This is what keeps me alive, my questioning everything and finding probable answers. Probable, because new facts can change everything. Cognitive dissonance is the enemy of discovery. I try to stop it when it raises its stupid head. I love finding out I was wrong, and why, and learning. Thank You! Of course, I subscribed. I look forward to learning every day. I am physically disabled and live in very serious pain because I will not kill my mind by using the meds the pain specialists have recommended. My thirst for knowledge has actually saved my life many times in many ways. Again, Thank You!

Thanks, new here, but boy, am I enjoying these short summations. Thank you for the great work. I've subscribed!

why am I discovering channels like this at 1am??? this is my 2nd video from the 2020's Biggest Breakthroughs series.

3:56 When you see his daughter sleeping in the left corner, but realize it's an individual of pillows.

In the last topic, it would be interesting to see how sleep deprivation affects the immune system, and if sleep deprivation affect the immune system in a similar way that stress does it, both causing release of ROS. Also, it could be interesting to stain and quantify for the different forms of the glutathione to get a GSH/GSSG ratio. The increase of ROS can be caused by an increase in the production of these molecules, caused by a decrease in the production of what is supposed to eliminate (GSH), or something else.

just discovered this channel, you've earned a subscriber. What an amazing quality of the content👌 keep up the good work

Imagine being one of those neurons firing in your brain right now, all collectively wondering about if they individually are conscious.

Third video... I really should get on with my day... lol keep making great content...as it happens sleep is the basis of my next video to be worked on. I read Martin Walker's book when it first came out and immediately improved my sleep routine.. my mental and physical health have never looked back and I was already exercising, eating healthy, meditating...etc., Now my sleep is locked down...it is a non-negotiable in my life.

"An individual is a process" Fantastic! Sometimes a phrase comes along that can utterly change a definition but it makes so much sense and deals with a lot of problems that come about when trying to define an individual.

There is something spooky about how many Asian philosophies kind got the gist of some major things in biology and science as a whole without much science. Particular how so many processes are cyclical, that we're 'all connected', etc.

@creativedesignation7880

3 жыл бұрын

I don't think it is spooky at all. It is two observers with different biases observing the same physical reality and comming to similar conclusions.

@jjt1881

3 жыл бұрын

I don't think Asian philosophers had any idea of any of those things. Saying that many processes are cyclical, is not saying much at all.

@robertlopez616

3 жыл бұрын

What you're referring to is reality is as it is.

@Kushufy

3 жыл бұрын

when people claim so many different things it's just statistically likely some of those claims are true, there's nothing spooky about it

@oneidea1121

3 жыл бұрын

All the cultures that evolved socially and technologicaly in the shorter time(egyptians, mayans, middle east) all had some sort of psychadelic drug Infused in they're culture, drugs that develop the perception of the conscius self, providing a higher cerebral activity, all of the psychadelic substances used by them evolved the know well known ego death effect and visualizations of mathematical and simetricaly abstract patterns, crazy to think that egypcians consumed psycadhelics on a regular bases. I did all my research you can do aswell Dmt producing psychadelic substances produce higher cerebral activity the highest activity of your life since the beginning of your own life, curious thing is that dmt is one of the chemicals that is only produced when you die. Ama please

I know there is a link to quanta magazine in the description above, but would there be the possibility of linking directly to specific relevant articles, or even one key paper? Or a key word that would produce a directly relevant collection of links?

Scientist: Describe their opinion Me: ok...🙄🤔 Narrator: explains Me : Ohoooo 🤯

@Meta2806

3 жыл бұрын

Their findings*, not their opinions though. Science is about facts, not beliefs.

I’m curious about the third one. In order to keep the animal subjects awake they had to keep them constantly moving and active, so I wonder if over-exertion is a factor. How does waking rest affect the oxidization ya know

Please continue this series.

very cool! could you provide citations for the papers mentioned? I would love to read/ reference the published works of these discoveries

Compared to older videos, I'm enjoying this longer form significantly more. It's also nice, personally, to focus on more concrete scientific focuses such as these (rather than occupational anecdotes lacking application).

This channel is now officially the year rewind.

Can you do a „Breakthroughs in Chemistry/Biochemistry“ Video? :)

I have Probable Autoimmune Encephalitis, its basically schizophrenia and I also have restless legs. I can't sleep and my symptoms are directly related to how well I sleep. I noticed my gut always feels odd or "queasy" when I wake up after sleeping only 2-5 hours a night, sometimes only half sleeping.

thank you for creating such wonderful content!! it is really helping me with my 2021 resolution to learn something interesting and new each day haha will definitely recommend it to more people

@sgtmayhem7567

2 жыл бұрын

That’s a really good philosophy.

Anyone know where to find that paper that talks about the dendritic spikes?

Could we please have some corresponding links for these discoveries :)

Learning stuff like this just makes me feel good about the world. 🤟🏽

Thank you for helping the world also stay at the forefront of all the interesting and life changing work that is being done in science This channel is a blessinggggggg Also keeps the world curious and motivated

wow we were actually taught about ros build up in the cells this year in pathology i dd not know it was a recent discovery. this gave me a whole new appreciation to my professors in Istanbul university faculty of medicine.

The fact that there are like 100 comments along the lines of "I'm up late, instead of sleeping. Time to die, I guess" makes me very concerned about people's intelectual capacity, aswell as their talent for humor.

@DavidSartor0

3 жыл бұрын

Much less than 100.

@jasonn5413

3 жыл бұрын

It’s just a comment. Doesn’t measure anything.

@lightmorrison5404

3 жыл бұрын

Try spelling intellectual correctly before calling out yt comments

@w0mblemania

3 жыл бұрын

You gotta love it when "intelectual" snobs forget to include words, and can't even spell.

@mr.knowitall5019

3 жыл бұрын

@@dupeken They are the same people lol.

from 3:11 Don't wanna be nitpicky here, but how is a mere theory a breakthrough? The clip doesn't provide proof or evidence like with the other examples.

@ThomasAndersonPhD

3 жыл бұрын

It also doesn't actually sound that novel, tbh. Of course the individual is a process through time. At least in my field in psychology/cognitive neuroscience, we've thought of it like that for at least a decade if not more.

@123TeeMee

3 жыл бұрын

@@ThomasAndersonPhD Doesn't even sound like biology to me

What an awesome and informative video depicted in a beautiful way. Thank you @Quanta Magazine :D

love the hard work you guys do.

I had insomnia for a year. Thought I was surely going to die. No idea what caused it. I changed my whole life just to try and get rid of insomnia. Alot was changed so i have no clue what it was eventually, dont remember much from the insomnia period but at least now I can actually feel tired at night and fall asleep. The 3 major things i did was: move to a quieter place. change my diet. Eating less meat among other things. stopped caring so much about my job. I stopped bringing work home.

Saying xor is commonly used in neural networks isn't wrong, it just doesn't make much sense. It's like saying the letter "A" is commonly seen on keyboards for small laptops... It's really seen everywhere else, and not specifically more or less in that situation. xor gates, just like other logic gates (and, or, not, nand, nor) are used to build the basic circuitry for computers and basic computing power, and are also commonly used (at least and, or, and not) in programming. A neural network basically just uses trial and error with a large data set to set a bunch of values between 0 and 1 to determine different weights should be assigned to get the correct output for each input. Unless you're saying something else that I'm not understanding....

the animation of the xor gate does not make sense to me :/ is the purple square supposed to be an OR gate? What is the yellow square? 🤦‍♂️

6:15 so admiral holdo is a biologist...

So doe this mean lack of sleep effects cellular respiration? Its it like when Your body uses lactic acid fermentation between the the cycle of cellular respiration to keep energy continuous and with lack of sleep it is unable too? Or what is it about sleep that creates oxidative stress

Simply the first two breakthroughs just sounded like physics , computer science and philosophical breakthroughs!

@rainofficial1924

3 жыл бұрын

That is why scientists work together nearly all the time

Is there going to be one for Chemistry? I would really enjoy one of them

I desperately need more channels like this

i love these videos but please cite the papers with a link in the future

This channel is simply amazing!

@Quanta Magazine Where/what is the "Sannafey" institute @3:44? Googed but can't locate.

@larimus724

3 жыл бұрын

They mean „Santa Fe“

@___Zack___

3 жыл бұрын

@@larimus724 Ah okay thanks, appreciate it! If someone can teach them the letter "t" it would be so helpful

Fantastic work in the first two cases. And fantastic cruelty on Dragana Rogulja's part in the third one.

The brain as a computer? Okay 2010

Thank you quanta magazine

that last one about sleep really got me...I'm going to bed bois. later

What cause-effect phenomena fall outside of the classification of computation?

everyone is saying this is a bad year but thankyou to show the positive side of this year

I love these, I could watch these types of videos all day.

Can't find any links to the first study, if someone has it please comment. Ty.

Please provide the paper references Great work btw..really really fantastic job

5:55 ...well crap, I guess I need to sleep

This is a wonderful video. Thank you very much!

Is oxidation this big of a problem for fungi?

The video - "Why sleep deprivation kills" Me (who hasn't slept yet and its 9am) - Hmm interesting

the "chips within a chip" makes a lot of sense. the computer business really took off after SoC matured

Couldnt have asked for a better christmas gift than finding this channel

I immediately paused on sleep deprivation and scanned through comments.

@jjt1881

3 жыл бұрын

Me too, I couldn't stomach the experiments on mice. Basically, this means killing mice by sleep deprivation and then directing their bodies.

The summary is excellent

This should be more popular

Excelente site!!! Indeed. Brasil

Awesome report. I have a question though in relation to third section what about fish? How does thier cells adapted to lack of sleep especially in sharks were constant movement is essential for thier survival.

@j10001

2 жыл бұрын

Great thought! I think I heard that they have discovered that sharks sleep. Sorry I cannot provide a reference right now.

I actually watched Solaris this year so cool!

After viewing this video I looked up David Krakauer's paper on his Information Theory of Individuality. This theory is absolutely fascinating!

And this is the reason I don't commit suicide. I want to see how far humanity can go.

@danielchang8704

3 жыл бұрын

And the reason I want to live long

Great as always...love ur channel and social handles...

@arthmendhe999

3 жыл бұрын

Same.

About sleep deprivation, I know this for years. since I remember My mom told me if I don't sleep well I will get old sooner than other people I get sick faster. She also told me about sunlight effects over the years, Well she was 96 years old when she died. Long-life with lots of knowledge never went to college just to 6 grade.. in 1930

I’ve read 40 pages of neuroscience for dummies and came to this same conclusion!! Insane

someone once explained to me that in a certain native american language, living things where described and understood as processes. like a tree is not perceived as merely a tree but a "treeing." it seems that the information theory of individuality may have been understood, at least intuitively, in other cultures

Me watching #3 on 4 hours of sleep 😭

@bobth3god

3 жыл бұрын

"oh great, i'm dying right now:"

@agape_99

3 жыл бұрын

Enjoy your free radicals bruh

@ArawnOfAnnwn

3 жыл бұрын

You'll never be able to actually do that. Your body won't let you. Even sleep deprivation torture requires constant oversight by the torturers. There are people who've been global circumnavigations in balloons who've wound up sleep deprived and almost fallen out of the sky just cos they were unable to stay awake. Regardless of how uncomfortable you are, your body won't let you go without sleep for more than a few days - and it takes a week or more of deprivation for it to actually start dying.

@overmeme953

3 жыл бұрын

@@ArawnOfAnnwn well I sleep 3 hours average per day soo

Thank you, Stuart, rest in peace

Are the elementary particles of atoms really knots of strange matter? It looks like obsolete material if it sleeps in a back-explosion into new material or such developments that entail additional complexity similar to obsolete material. Could they be there as a contamination (negligible but present) or short-lived issue? This may be unknown or well-known, but may be discovered and understood by further studies of torsional mathematics or other switches in the problem of complex and less interesting particles.

This last discovery would give support to the hypothesis that sleep deprivation is partially responsible for some forms of obesity. We already know that gut dysfunction & inflammation can trigger hypotrophy in Adipocytes, but that the sleep function (controlled & modulated by the brain through the Pineal ⇄ Suprachiasmatic Nucleus pathway) is also necessary for supressing Reactive Oxygen Species (ROR), & therefore maintaining gastrointestinal health, is an intriguing new part of the puzzle.

Thank you for these incredible

McCulloch and Pitts have shown in their paper in 1943 that a very small two layered neural network can be trained to solve XOR problem contrary to what the researcher in the beginning says that a large neural network is needed for solving XOR. However, image recognition does require very huge and complex neural network called deep neural networks. It would be best if I read her paper and understand it before commenting any further but I didn't quite understand why she said that a large neural network is needed to solve XOR.

Interesting. The individuality perspective is aligned to process philosophy of the post-modern era. Not a new way of thinking, but certainly fundamental to fit under the scientific method if philosophers were correct!

Next level production

5:20 Lem approve this message.

what does anyone think on the logic if the stimuly is smaller then the amplitude is larger ?

All I can think about is how me and so many others have to work full time and go to school fulltime and we are loosing so much sleep and pulling all nighters sometimes and then have the stress of passing exams and having money to pay for school, housing, and bills and just everyday stress.... this made me sad to think about my cells dying :(

I always get recommended the good stuff

What are anyone's thoughts on taking antioxidants to reduce the negative impact of sleep deprivation for those who have to go through it for whatever reason?

That Theory of Individuality is particularly interesting to me. One of the most fascinating creatures, in my opinion, is the siphonophore. Like other colonial animals, the individual zooids that compromise the specimen are indistinguishable from each other. They all play different roles (some feeding, some locomotive, etc), and all roles are necessary to the success of the entire creature. So, is the siphonophore equal to the sum of its parts? Does each zooid exist as an individual? Or does it only count when the zooids are all attached to each other and functioning in a macro way? At what point does the siphonophore cease to be simply zooids stuck together and start being considered an actual siphonophore? Colonialism exists throughout the natural world in so many different forms. It will be interesting to follow this field of study.

Thank you very much publisher,gives insight and hope.

How are spatial and temporal terms not the same?

The indaviduality discussion sounds like they reinvented Difference and Repetition by Deleuze

Quanta: Sleep Deprivation Kills Me watching at 3am: Guess I’m dead now