13.6 Ring Opening of Epoxides | Organic Chemistry

Chad provides a comprehensive lesson on the Ring Opening of Epoxides. This can be done under two conditions with varying regiospecificity, and ring opening in the presence of a strong nucleophile is covered first (sometimes called base catalyzed ring opening of epoxides), while acid catalyzed ring opening of epoxides is covered second. Chad concludes the lesson by providing an example of Grignard addition to an epoxide.
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00:00 Lesson Introduction
00:26 Ring Opening of Epoxides with Strong Nucleophiles
3:17 Acid-Catalyzed Ring Opening of Epoxides
8:39 Grignard Addition to Epoxides

Пікірлер: 55

  • @Syllonay
    @Syllonay3 жыл бұрын

    That might have been the best chemistry lecture I ever had. You are genuine, funny, interesting and straight to the point. Thank you for your excellent teaching sir, it helped me tremendously

  • @ChadsPrep

    @ChadsPrep

    3 жыл бұрын

    You are very welcome, MangeUlver - thank you for saying so!

  • @DallinPlatt
    @DallinPlattАй бұрын

    Idk what it is about these videos but they make so much sense

  • @ChadsPrep

    @ChadsPrep

    Ай бұрын

    Glad they do!

  • @rajikarobinson122
    @rajikarobinson1222 жыл бұрын

    Thank you so much! This was the best lecture on ring opening of epoxides that I've ever seen.

  • @ChadsPrep

    @ChadsPrep

    2 жыл бұрын

    You're welcome, Rajika Robinso - glad it helped!

  • @amalgregory4375
    @amalgregory43752 жыл бұрын

    Thank you so much! I've been scratching my head for an hour with two different textbooks but this sorted it all out clearly. Ur amazing!

  • @ChadsPrep

    @ChadsPrep

    2 жыл бұрын

    Glad you found the channel and the video so helpful, Amal Gregory - Happy Studying!

  • @Vinayak_Nair
    @Vinayak_Nair2 жыл бұрын

    You explained this concept so well! Thank you.

  • @ChadsPrep

    @ChadsPrep

    2 жыл бұрын

    You're welcome!

  • @Czar_Char
    @Czar_Char Жыл бұрын

    i keep saying this man needs an award.........and i'mma keep saying it!!!! Big up from Ghana

  • @ChadsPrep

    @ChadsPrep

    Жыл бұрын

    Thank you, from U.S.A. - Happy Studying!

  • @emiliolarrazabal5360
    @emiliolarrazabal53602 жыл бұрын

    This is the best breakdown of epoxide reactions online

  • @ChadsPrep

    @ChadsPrep

    2 жыл бұрын

    Glad to hear it, Emilio!

  • @ccoppola11
    @ccoppola113 жыл бұрын

    this was so helpful! great video

  • @ChadsPrep

    @ChadsPrep

    3 жыл бұрын

    Glad you think so, Cararose - thanks for commenting!

  • @kanchanmotwani4305
    @kanchanmotwani43053 жыл бұрын

    Thank you-this helped me so much!

  • @ChadsPrep

    @ChadsPrep

    3 жыл бұрын

    You're welcome, Kanchan. Thank you for the feedback.

  • @WomannequinReviews
    @WomannequinReviews Жыл бұрын

    What would happen with the methyl group during the ring opening if it was neither dashed nor wedged from the start? Would it remain unchanged at the end of the reaction or would it become dashed or wedged?

  • @ADPL-tn5ix
    @ADPL-tn5ix2 ай бұрын

    Amazing lecture sir, thank you

  • @ChadsPrep

    @ChadsPrep

    2 ай бұрын

    You're welcome and Thank You.

  • @target__iit
    @target__iit10 ай бұрын

    Absolutely worth it 👍

  • @ChadsPrep

    @ChadsPrep

    10 ай бұрын

    Thank you

  • @borzoo
    @borzoo Жыл бұрын

    thank you very much for great lecture

  • @ChadsPrep

    @ChadsPrep

    Жыл бұрын

    You're welcome.

  • @stephennguni1145
    @stephennguni11453 жыл бұрын

    Great video keep up

  • @ChadsPrep

    @ChadsPrep

    3 жыл бұрын

    Thanks, Stephen!

  • @laavanyarajan4444
    @laavanyarajan4444 Жыл бұрын

    The best, thank you sir...

  • @ChadsPrep

    @ChadsPrep

    Жыл бұрын

    You're welcome!

  • @gracerl
    @gracerl Жыл бұрын

    This is the video that made me subscribe

  • @ChadsPrep

    @ChadsPrep

    Жыл бұрын

    Welcome to the channel :)

  • @isaacotto3202
    @isaacotto3202 Жыл бұрын

    Thanks alot sir!

  • @ChadsPrep

    @ChadsPrep

    Жыл бұрын

    Very welcome.

  • @thedarkknight1865
    @thedarkknight18652 жыл бұрын

    Thanks 😃💖 you're best 😎👍

  • @ChadsPrep

    @ChadsPrep

    2 жыл бұрын

    Thanks and you're welcome!

  • @zcarinareimuyargas5793
    @zcarinareimuyargas5793 Жыл бұрын

    hi! what happen to the H2SO4 number 2 example?

  • @matthewclaveria8348

    @matthewclaveria8348

    7 ай бұрын

    It was just used to protonate the alcohol (CH3-OH)

  • @rickyl7442
    @rickyl74423 ай бұрын

    I have a question, so idk if this is just a professor preference thing but for acid catalyzed ring opening my professor has the CH3OH on the top and then HCl (cat) on the bottom. So I was wondering of the placement of this means anything at all or if it doesn’t matter. Because your way makes a lot more sense.

  • @ChadsPrep

    @ChadsPrep

    3 ай бұрын

    Do you mean above/below the arrow? There is no set rule, but the reagent tends to be written above the arrow and anything else, solvent etc below.

  • @rf9674
    @rf96742 жыл бұрын

    YOU ARE AMAZING WOW

  • @ChadsPrep

    @ChadsPrep

    2 жыл бұрын

    THANKS!

  • @eseegs
    @eseegs7 ай бұрын

    Why would the positively charged pronated epoxide not first lose the bond to the carbon to become neutral and causing a full carbocation on the tertiary carbon. Then the weak nucleophiel could attack either side like a typical SN1 reaction. Why does this not happen?

  • @ChadsPrep

    @ChadsPrep

    6 ай бұрын

    Hey there, I mention a few times in the video that it can occur in an SN1 type reaction, where the O-C bond on the more substituted side will be longer and weaker than the other side (as if the ring were starting to open in that way before the nucleophile attacks) leaving a more positive tertiary carbon.

  • @verisa19
    @verisa1910 ай бұрын

    I’ve a doubt, what happend with H2SO4?

  • @matthewclaveria8348

    @matthewclaveria8348

    7 ай бұрын

    H2SO4 was just used to protonate the alcohol (CH3-OH), I assume it can also activate the epoxide without having to protonate the alcohol first but both scenario works.

  • @target__iit
    @target__iit10 ай бұрын

    This guy never fails to reply to comments 🙃

  • @ChadsPrep

    @ChadsPrep

    10 ай бұрын

    Trying....not....to....comment....CAN'T!! 😀 😀 😀

  • @target__iit
    @target__iit4 ай бұрын

    Hey i'm back 🧤

  • @ChadsPrep

    @ChadsPrep

    4 ай бұрын

    Welcome back and Happy Studying!

  • @laura5878
    @laura5878 Жыл бұрын

    My exam is coming up, can I rub your head for good luck?

  • @ChadsPrep

    @ChadsPrep

    Жыл бұрын

    If you mean by rubbing my head that you watch every video 3 times, then GO FOR IT! 🙂

  • @suyashdave9642
    @suyashdave964210 ай бұрын

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  • @ChadsPrep

    @ChadsPrep

    10 ай бұрын

    Thanks!